ANZTCT practice statement: sinusoidal obstruction syndrome/veno-occlusive disease diagnosis and management

Shaun Fleming¹, Ashleigh P Scott², John Coutsouvelis^{3

4}, Chris Fraser⁵, Ashish Bajel^{6

7}, Adam Nelson⁸, Rachel Conyers^{9

10

11}, Ashley McEwan^{12

13}, David Yeung¹⁴, Victoria Campion¹⁵, Lochie Teague¹⁶, Matthew McGuire¹⁷, Edward Morris¹⁸, Melissa Gabriel¹⁹, Rebecca Wayte²⁰, Genevieve Douglas²¹, Nicole Chien²², Nada Hamad^{23

24

25}

Affiliations

¹ Clinical Haematology, Alfred Hospital and Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia.
² Department of Haematology and Bone Marrow Transplant, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
³ Pharmacy Department, Alfred Health, Melbourne, Victoria, Australia.
⁴ Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia.
⁵ Blood and Marrow Transplant Service, Queensland Children's Hospital, Brisbane, Queensland, Australia.
⁶ Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, Victoria, Australia.
⁷ Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia.
⁸ Kids Cancer Centre, Sydney Children's Hospital, Sydney, New South Wales, Australia.
⁹ Pharmacogenomics Team, Stem Cell Biology, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
¹⁰ Children's Cancer Centre, The Royal Children's Hospital, Melbourne, Victoria, Australia.
¹¹ Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia.
¹² Haematology Department, Liverpool Hospital, Sydney, New South Wales, Australia.
¹³ South West Sydney Clinical School, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
¹⁴ Royal Adelaide Hospital and Adelaide Medical School, Adelaide, South Australia, Australia.
¹⁵ Wellington Blood and Cancer Centre, Wellington Hospital, Wellington, New Zealand.
¹⁶ Starship Blood and Cancer Center, Starship Children's Hospital, Auckland, New Zealand.
¹⁷ Department of Pharmacy, Fiona Stanley Hospital, Perth, Western Australia, Australia.
¹⁸ Department of Haematology and Bone Marrow Transplantation, Townsville University Hospital, Townsville, Queensland, Australia.
¹⁹ Cancer Centre for Children, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.
²⁰ Department of Haematology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
²¹ Clinical Haematology, Austin Health, Melbourne, Victoria, Australia.
²² Department of Haematology, Auckland City Hospital, Auckland, New Zealand.
²³ Department of Haematology, St Vincent's Hospital Sydney, Sydney, New South Wales, Australia.
²⁴ School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.
²⁵ School of Medicine, University of Notre Dame, Sydney, New South Wales, Australia.

PMID: 39076028
DOI: 10.1111/imj.16453

Review

ANZTCT practice statement: sinusoidal obstruction syndrome/veno-occlusive disease diagnosis and management

Shaun Fleming et al. Intern Med J. 2024 Sep.

. 2024 Sep;54(9):1548-1556.

doi: 10.1111/imj.16453. Epub 2024 Jul 30.

Authors

Affiliations

¹ Clinical Haematology, Alfred Hospital and Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia.
² Department of Haematology and Bone Marrow Transplant, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
³ Pharmacy Department, Alfred Health, Melbourne, Victoria, Australia.
⁴ Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia.
⁵ Blood and Marrow Transplant Service, Queensland Children's Hospital, Brisbane, Queensland, Australia.
⁶ Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, Victoria, Australia.
⁷ Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia.
⁸ Kids Cancer Centre, Sydney Children's Hospital, Sydney, New South Wales, Australia.
⁹ Pharmacogenomics Team, Stem Cell Biology, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
¹⁰ Children's Cancer Centre, The Royal Children's Hospital, Melbourne, Victoria, Australia.
¹¹ Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia.
¹² Haematology Department, Liverpool Hospital, Sydney, New South Wales, Australia.
¹³ South West Sydney Clinical School, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
¹⁴ Royal Adelaide Hospital and Adelaide Medical School, Adelaide, South Australia, Australia.
¹⁵ Wellington Blood and Cancer Centre, Wellington Hospital, Wellington, New Zealand.
¹⁶ Starship Blood and Cancer Center, Starship Children's Hospital, Auckland, New Zealand.
¹⁷ Department of Pharmacy, Fiona Stanley Hospital, Perth, Western Australia, Australia.
¹⁸ Department of Haematology and Bone Marrow Transplantation, Townsville University Hospital, Townsville, Queensland, Australia.
¹⁹ Cancer Centre for Children, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.
²⁰ Department of Haematology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
²¹ Clinical Haematology, Austin Health, Melbourne, Victoria, Australia.
²² Department of Haematology, Auckland City Hospital, Auckland, New Zealand.
²³ Department of Haematology, St Vincent's Hospital Sydney, Sydney, New South Wales, Australia.
²⁴ School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.
²⁵ School of Medicine, University of Notre Dame, Sydney, New South Wales, Australia.

PMID: 39076028
DOI: 10.1111/imj.16453

Abstract

Sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) is a life-threatening complication which can develop after haemopoietic stem cell transplantation (HSCT) and some antibody-drug conjugates. Several SOS/VOD diagnostic and management guidelines exist, with the most recent and refined being the European Society for Blood and Marrow Transplantation adult and paediatric guidelines. Timely diagnosis and effective management (including the availability of therapeutic options) significantly contribute to improved patient outcomes. In Australia and New Zealand, there is variability in clinical practice and access to SOS/VOD therapies. This review aims to summarise the current evidence for SOS/VOD diagnosis, prevention and treatment and to provide recommendations for SOS/VOD in the context of contemporary Australasian HSCT clinical practice.

Keywords: SOS/VOD; haemopoietic stem cell transplantation; sinusoidal obstruction syndrome; sinusoidal obstruction syndrome/veno‐occlusive disease.

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References

1. Carreras E. Veno‐occlusive disease of the liver after hemopoietic cell transplantation. Eur J Haematol 2000; 64: 281–291.
1. Bonifazi F, Barbato F, Ravaioli F, Sessa M, Defrancesco I, Arpinati M et al. Diagnosis and treatment of VOD/SOS after allogeneic hematopoietic stem cell transplantation. Front Immunol 2020; 11: 489.
1. Mohty M, Malard F, Alaskar AS, Aljurf M, Arat M, Bader P et al. Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno‐occlusive disease in adult patients: a refined classification from the European Society for Blood and Marrow Transplantation (EBMT). Bone Marrow Transplant 2023; 58: 749–754.
1. Corbacioglu S, Carreras E, Ansari M, Balduzzi A, Cesaro S, Dalle JH et al. Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno‐occlusive disease in pediatric patients: a new classification from the European society for blood and marrow transplantation. Bone Marrow Transplant 2018; 53: 138–145.
1. Fujishima N, Uchida T, Onishi Y, Jung CW, Goh YT, Ando K et al. Inotuzumab ozogamicin versus standard of care in Asian patients with relapsed/refractory acute lymphoblastic leukemia. Int J Hematol 2019; 110: 709–722.

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ANZTCT practice statement: sinusoidal obstruction syndrome/veno-occlusive disease diagnosis and management

Affiliations

ANZTCT practice statement: sinusoidal obstruction syndrome/veno-occlusive disease diagnosis and management

Authors

Affiliations

Abstract

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Full Text Sources