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Review
. 2023 Mar 23;24(4):96.
doi: 10.31083/j.rcm2404096. eCollection 2023 Apr.

Role of LncRNAs in the Pathogenesis of Coronary Artery Disease

Xinyu Wu  1 , Jingru Li  1 , Guihu Sun  1 , Jun Yang  1 , Yunzhu Peng  1 , Xiangfeng Bai  2 , Luqiao Wang  1
Affiliations
Review

Role of LncRNAs in the Pathogenesis of Coronary Artery Disease

Xinyu Wu et al. Rev Cardiovasc Med. .

Abstract

Coronary artery disease (CAD), caused by coronary artery occlusion, is a common cardiovascular disease worldwide. Long non-coding RNAs (lncRNAs) are implicated in the regulation of endothelial cell injury, angiogenesis, plaque formation, and other pathological mechanisms in CAD by acting on different cell types. Some lncRNAs are significantly upregulated in CAD patients; however, other lncRNAs are significantly downregulated. Differential expression of lncRNAs in CAD patients enables them to be exploited as potential biomarkers to evaluate disease progression and diagnosis/prognosis in CAD patients. In this study, we reviewed the role of lncRNAs in the development of different clinical subtypes of CAD.

Keywords: cardiac fibroblasts; cardiomyocytes; coronary artery disease; diagnostic biomarkers; endothelial cells; lncRNA; vascular smooth muscle cells.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
LncRNAs as biomarkers of CAD participate in pathological processes and then affect the occurrence and development of CAD. Abbreviations: ECs, endothelial cells; VSMCs, vascular smooth muscle cells; CM, cardiomyocyte; CF, cardiac fibrosis.
See this image and copyright information in PMC

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