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Case Reports
. 2024 Jun 27;16(6):e63329.
doi: 10.7759/cureus.63329. eCollection 2024 Jun.

Recurrent Hypoglycemia in a Non-diabetic Female: A Case Study on Doege-Potter Syndrome

Saeed R Mohammed  1 , Narine Mack  2 , Valmikie Ramoutar  2 , Jessica Rampersad  2
Affiliations
Case Reports

Recurrent Hypoglycemia in a Non-diabetic Female: A Case Study on Doege-Potter Syndrome

Saeed R Mohammed et al. Cureus. .

Abstract

Solitary fibrous tumors (SFT) are mesenchymal cell tumors that may arise from any site throughout the body. A small percentage of patients with SFT develop non-islet cell tumor-induced hypoglycemia (NICTH), eponymously termed Doege-Potter Syndrome (DPS). DPS is characterized by severe, refractory hypoinsulinemic hypoglycemia. Diagnosis of SFT is dependent on histologic findings and immunohistochemistry (IHC). NAB2-STAT6 gene fusions are pathognomonic for SFT but may be difficult to identify in routine cytogenetic studies. STAT6 IHC is a highly sensitive and specific surrogate for the NAB2-STAT6 gene fusion. Total resection of the tumor remains the gold-standard definitive treatment of SFT of the pleura. Palliative tumor debulking is recommended if total resection is not feasible. We here report a case of DPS in a 73-year-old female, managed with palliative care.

Keywords: endocrinology; hypoglycemia; recurrent hypoglycemia; solitary fibrous pleural tumour; solitary fibrous tumor.

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Conflict of interest statement

Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. CT coronal IV contrast image demonstrates caudal effacement of the diaphragm with mass effect on the subdiaphragmatic structures such as the liver.
CT: computed tomography; IV: intravenous
Figure 2
Figure 2. CT sagittal IV contrast demonstrates the large lesion limited by the diaphragm with no evidence of intraabdominal extension.
CT: computed tomography; IV: intravenous
Figure 3
Figure 3. CT illustrating an axial image of a large infiltrative lesion occupying the right mid-lower lobe region of the hemithorax and displacement of the mediastinum to the left.
CT: computed tomography
Figure 4
Figure 4. Lung biopsy specimen displaying spindle cells arranged in a storiform pattern in addition to vague fascicular and haphazard patterns with collagenous stroma.
See this image and copyright information in PMC

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