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Review
. 2024 Feb 5;25(2):56.
doi: 10.31083/j.rcm2502056. eCollection 2024 Feb.

Circulating Myokines as Novel Biomarkers for Cardiovascular Diseases

Jin-Xiu Lyu  1 , Dan-Dan Guo  1   2 , Yu-Chen Song  1   2 , Man-Ru Zhang  1   3 , Feng-Qin Ge  1 , Jing Zhao  1 , Hua Zhu  1 , Peng-Zhou Hang  1
Affiliations
Review

Circulating Myokines as Novel Biomarkers for Cardiovascular Diseases

Jin-Xiu Lyu et al. Rev Cardiovasc Med. .

Abstract

Myokines are a group of cytokines or polypeptides released from skeletal muscle during exercise. Growing evidence suggests that myokines are associated with the development of cardiovascular disease (CVD). Moreover, several myokines in peripheral blood exhibit dynamic changes in different CVD stages. This review summarizes the potential roles of myokines such as myostatin, irisin, brain-derived neurotrophic factor, mitsugumin 53, meteorin-like, and apelin in various CVD, including myocardial infarction, heart failure, atherosclerosis, hypertension, and diabetes. The association of these myokines with biomarkers currently being used in clinical practice is also discussed. Furthermore, the review considers the emerging role of myokines in CVD and addresses the challenges remaining in translating these discoveries into novel clinical biomarkers for CVD.

Keywords: biomarker; cardiovascular diseases; myokine.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Association between circulating myokines and cardiovascular diseases including myocardial infarction, heart failure, atherosclerosis, diabetes, and hypertension. Metrnl, meteorin-like; MG53, mitsugumin 53; BDNF, brain-derived neurotrophic factor; FSTL1, follistatin-like 1; DCN, decorin.
See this image and copyright information in PMC

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