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Review
. 2024 Jul 15:14:1420854.
doi: 10.3389/fcimb.2024.1420854. eCollection 2024.

Exploring TRIM proteins' role in antiviral defense against influenza A virus and respiratory coronaviruses

Ying Wei  1   2   3 , Junzhu Song  1   2   3 , Jingyu Zhang  1   2   3 , Songbiao Chen  1   2   3 , Zuhua Yu  1   2   3 , Lei He  1   2   3 , Jian Chen  1   2   3
Affiliations
Review

Exploring TRIM proteins' role in antiviral defense against influenza A virus and respiratory coronaviruses

Ying Wei et al. Front Cell Infect Microbiol. .

Abstract

Numerous tripartite motif (TRIM) proteins, identified as E3 ubiquitin ligases, participate in various viral infections through ubiquitylation, ISGylation, and SUMOylation processes. Respiratory viruses, particularly influenza A virus (IAV) and respiratory coronaviruses (CoVs), have severely threatened public health with high morbidity and mortality, causing incalculable losses. Research on the regulation of TRIM proteins in respiratory virus infections is crucial for disease prevention and control. This review introduces TRIM proteins, summarizes recent discoveries regarding their roles and molecular mechanisms in IAV and CoVs infections, discusses current research gaps, and explores potential future trends in this rapidly developing field. It aims to enhance understanding of virus-host interactions and inform the development of new molecularly targeted therapies.

Keywords: TRIM proteins; influenza A virus; innate immunity; respiratory coronavirus; viral components.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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