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Review
. 2023 Oct 7;24(10):276.
doi: 10.31083/j.rcm2410276. eCollection 2023 Oct.

Research Advances in Targeted Therapy for Heart Failure

Liu Miao  1 , Yan-Li Liu  1
Affiliations
Review

Research Advances in Targeted Therapy for Heart Failure

Liu Miao et al. Rev Cardiovasc Med. .

Abstract

Cardiovascular disease is one of the major diseases threatening the health of Chinese residents, and the death rate has long been the highest on the disease spectrum in China. With the progress of population aging, the prevalence and mortality of cardiovascular diseases remain on the rise, and the current treatment effect on and prognosis of heart failure (HF) are not satisfactory. It is particularly important to explore the potential pathogenic mechanisms of HF and identify new therapeutic targets.

Keywords: HF; gene therapy; intestinal flora; mitochondrial autophagy; signaling channels; targeted therapy.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Wnt signaling pathway and heart failure. DKK, Dickkopf; WIF1, WNT inhibitory factor 1; BRG1, Brahma-related gene 1; Krm, Kremen; LRP5/6, lipoprotein receptor-related protein 5/6; FRP, Frizzled receptor proteins; Dsh, Dishevelled; GSK3β, glycogen synthase kinase 3β; APC, APC regulator of WNT signaling pathway; AXIN, axin protein; Ctnn-β, Catenin Beta; Rac1, Rac Family Small GTPase 1; DAMM1/2, Dishevelled Associated Activator Of Morphogenesis 1/2 MAPSKs, Mitogen‑activated protein kinase; MAPKK4/7, Mitogen-activated protein kinase kinase 4/7; JNK, c-Jun N-terminal kinase; ROCK2, Rho Associated Coiled-Coil Containing Protein Kinase 2; RhoA, Ras homolog family member A; cox2, Cyclooxygenase-2; ENC1, ectodermal-neural cortex 1; c-Jun, Transcription factor Jun; NRCAM, Neuronal Cell Adhesion Molecule; FRA1, Fos-related antigen1; Cldn1, Claudin 1; TCF1, T cell factor 1; PPARδ, peroxisome proliferator-activated receptors; CREB, cAMP response element binding protein; c-Myc, MYC proto-oncogene; MMP7, Matrix Metallopeptidase 7; uPAR, urokinase plasminogen activator surface receptor; p53, Tumor protein P53; Pygo1/2, Pygopus Family PHD Finger 1; BCL9, B cell lymphoma 9; TCF/LEF, T-cell factor/lymphoid enhancer factor; CBP, CREB binding protein; β-Tcrp, β-tranducin repeats containing protein; Ubc4, ubiquitin conjugating enzyme 4.
See this image and copyright information in PMC

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