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Review
. 2024 Jan-Dec:12:23247096241262702.
doi: 10.1177/23247096241262702.

Dermatomyositis Associated With High-Grade B-Lymphoproliferative Disorders: A Case Report and Literature Review

Jun Yen Ng  1 , Mridula Mokoonlall  1 , Hana Kawatu  1 , Fathima Ayyalil  1 , Chandima Perera  1 , Adrienne Morey  1 , Nalini K Pati  1
Affiliations
Review

Dermatomyositis Associated With High-Grade B-Lymphoproliferative Disorders: A Case Report and Literature Review

Jun Yen Ng et al. J Investig Med High Impact Case Rep. 2024 Jan-Dec.

Abstract

Dermatomyositis (DM) and polymyositis are idiopathic inflammatory myopathies (IIMs), most associated with solid organ malignancies, and less commonly hematological malignancies. We discuss a case of DM associated with diffuse large B-cell lymphoma, followed by a review of literature on the pathogenesis, clinical course, treatment, and prognosis. Various challenges with the diagnosis and management of underlying lymphoproliferative disorders (LPDs) in patients with IIM are discussed. The case demonstrates the importance of being vigilant of the association between IIM and LPD. Cancer screening in patients with IIM is discussed, including the recently published International Guideline for IIM-Associated Cancer Screening. More research is required to address knowledge gaps in cancer screening in IIM.

Keywords: B-LPD; dermatomyositis; diagnostic challenge; diffuse large B-cell lymphoma.

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Conflict of interest statement

Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Cutaneous punch biopsy with mild vacuolar interface change along the dermoepidermal junction, occasional Civatte bodies (↓), some pigment incontinence in papillary dermis (△) and perivascular lymphocytic infiltrate in upper dermis.
Figure 2.
Figure 2.
Lymph node excision biopsy showing diffuse infiltrate of large pleomorphic lymphoid cells with prominent nucleoli and plentiful mitotic figures (↓).
See this image and copyright information in PMC

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