Disclosures of conflicts of interest: M.A.B. No relevant relationships. F.J.F. Research support from Pfizer; consulting fees from Boston Scientific; payment or honoraria for lectures from Boston Scientific. A.J.I. Royalties or licenses from Invitae, IDT; consulting fees from SequreDX, Intellia, Kinnate Biopharma; stock/stock options from Oncoclinicas Brazil, Kinnate Biopharma, Paige.AI. I.D.J. Consulting fees from AstraZeneca, Boehringer Ingelheim, Bayer, BostonGene, Bristol Meyers Squibb, Catalyst, Genentech, Gilead, Janssen, Merus, Novocure, Pfizer, Roche, Sanofi-Genzyme, Syros, ThermoFisher Scientific, Xcovery; payment or honoraria for lectures from Foundation Medicine, Creative Education Concepts, OncLive, ASCO Post, DAVA Oncology, Medscape, Research to Practice, Total Health, Aptitude Health, American Lung Association, PeerView. K.J.D. No relevant relationships. D.N.L. President of the International Society of Neuropathology. J.A.B. Board of Directors for Accumen. J.K.L. Employed by BostonGene.