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. 2024;76(10):902-913.
doi: 10.1080/01635581.2024.2385167. Epub 2024 Jul 30.

Effects of Antioxidant Dietary Supplement Use upon Response to Cancer Treatment: A Scoping Review of Available Evidence

L Susan Wieland  1   2 , Sydney Shade  3   4 , Ilana Moffet  5 , Amir Ansari  6 , Ashkan Emadi  4   6   7   8   9 , Cheryl L Knott  6   10 , Emily F Gorman  11 , Christopher R D'Adamo  1
Affiliations

Effects of Antioxidant Dietary Supplement Use upon Response to Cancer Treatment: A Scoping Review of Available Evidence

L Susan Wieland et al. Nutr Cancer. 2024.

Abstract

Introduction: The effects of antioxidant dietary supplements on response to biological therapies for cancer is unknown. We conducted a scoping review of the available systematic review evidence on this question.

Methods and analysis: We searched six databases from inception to August 19, 2022 for systematic reviews of randomized controlled trials of antioxidant dietary supplements used by patients receiving curative chemotherapy, radiotherapy, or other biological therapy for cancer and assessing the impact of supplements on survival, treatment response, or disease progression. We focused on results from reviews at high or moderate AMSTAR-2 quality. Records were selected, data extracted, and AMSTAR-2 ratings assessed independently by two authors.

Results: We found 24 systematic reviews with relevant evidence. Reviews were heterogenous in cancers, treatments, and antioxidant dietary supplements assessed. Conclusions across reviews were mixed, ranging from negative to no apparent difference to positive, but always with caveats about the limited size and quality of the evidence. One review was rated 'moderate' on AMSTAR-2; it included one small trial of vitamin C and formed no firm conclusions.

Conclusions: We did not find reliable systematic review evidence on the effects of antioxidant dietary supplements upon therapies for cancer. More research is necessary to inform clinical recommendations.

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Conflict of interest statement

Competing interests: The authors report there are no competing interests to declare.

Figures

Figure 1.
Figure 1.
Algorithm for study inclusion and exclusion
Figure 2.
Figure 2.
PRISMA flowchart
See this image and copyright information in PMC

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