Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Dec;21(6):604-614.
doi: 10.1007/s11897-024-00676-8. Epub 2024 Jul 30.

Cardiogenic Shock: Focus on Non-Cardiac Biomarkers

Hadi Beaini  1 , Zainali Chunawala  1   2 , Daniel Cheeran  1   3 , Faris Araj  1   2 , Christopher Wrobel  1   2 , Lauren Truby  1   2 , Amit Saha  1   2 , Jennifer T Thibodeau  1   2 , Maryjane Farr  4   5
Affiliations
Review

Cardiogenic Shock: Focus on Non-Cardiac Biomarkers

Hadi Beaini et al. Curr Heart Fail Rep. 2024 Dec.

Abstract

Purpose of review: To examine the evolving multifaceted nature of cardiogenic shock (CS) in the context of non-cardiac biomarkers that may improve CS management and risk stratification.

Recent findings: There are increasing data highlighting the role of lactate, glucose, and other markers of inflammation and end-organ dysfunction in CS. These biomarkers provide a more comprehensive understanding of the concurrent hemo-metabolic and cellular disturbances observed in CS and offer insights beyond standard structural and functional cardiac assessments. Non-cardiac biomarkers both refine the diagnostic accuracy and improve the prognostic assessments in CS. Further studies revolving around novel biomarkers are warranted to support more targeted and effective therapeutic and management interventions in these high-risk patients.

Keywords: Biomarkers; Cardiogenic shock; Non-cardiac biomarkers; Risk stratification.

PubMed Disclaimer

References

    1. Van Diepen S, Katz JN, Albert NM, Henry TD, Jacobs AK, Kapur NK, et al. Contemporary management of cardiogenic shock: a scientific statement from the American Heart Association. Circulation. 2017;136(16):e232–68. - PubMed
    1. Zeymer U, Bueno H, Granger CB, Hochman J, Huber K, Lettino M, et al. Acute Cardiovascular Care Association position statement for the diagnosis and treatment of patients with acute myocardial infarction complicated by cardiogenic shock: A document of the Acute Cardiovascular Care Association of the European Society of Cardiology. Eur Heart J Acute Cardiovasc Care. 2020;9(2):183–97. - PubMed - DOI
    1. Tehrani BN, Truesdell AG, Psotka MA, Rosner C, Singh R, Sinha SS, et al. A standardized and comprehensive approach to the management of cardiogenic shock. Heart failure. 2020;8(11):879–91. - PubMed
    1. Hochman JS. Cardiogenic shock complicating acute myocardial infarction: expanding the paradigm. Circulation. 2003;107(24):2998–3002. - PubMed - DOI
    1. Ghionzoli N, Sciaccaluga C, Mandoli G, Vergaro G, Gentile F, D’ascenzi F, et al. Cardiogenic shock and acute kidney injury: the rule rather than the exception. Heart Fail Rev. 2021;26:487–96. - PubMed - DOI

LinkOut - more resources