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. 2024 Nov 1;49(11):1606-1610.
doi: 10.1139/apnm-2024-0046. Epub 2024 Jul 30.

DXA-derived abdominal fat-free mass to predict MRI skeletal muscle mass in postmenopausal women

E Walker  1 , A M Chalke  1 , V L Bland  2 , K E Lind  3 , Z Chen  1 , R M Blew  3 , A O Odegaard  4 , C A Thomson  3 , B Caan  5 , J S Nicholas  6 , C I Valencia  7 , D J Roe  1 , M Allison  8 , P F Schnatz  9 , J Wactawski-Wende  10 , J W Bea  3
Affiliations

DXA-derived abdominal fat-free mass to predict MRI skeletal muscle mass in postmenopausal women

E Walker et al. Appl Physiol Nutr Metab. .

Abstract

Dual-energy X-ray absorptiometry (DXA) is more available than gold-standard magnetic resonance imaging (MRI), but DXA ability to estimate abdominal skeletal muscle mass (SMM) is unknown. DXA-derived abdominal fat-free mass (FFM; Hologic QDR2000 or QDR4500w) was correlated with single-slice MRI SMM at L4 (N = 69; r QDR2000 = 0.71, QDR4500w = 0.69; p < 0.0001). Linear regression to predict SMM, including DXA FFM, BMI, and age, resulted in an R-squared of 0.72 and 0.65 for QDR2000 and QDR4500. Bland-Altman limits of agreement were ±21 and ±31 g for 2-3 standard deviations from the mean difference. DXA predicted abdominal SSM is a moderate proxy for MRI abdominal SMM.

Keywords: abdominal muscle mass; absorptiometry; body composition; lean mass; magnetic resonance imaging; postmenopause.

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Conflict of interest statement

Dr. Bea would like to disclose board membership for the Global Health and Body Composition Institute and a contract with Disarm Therapeutics, Inc. for an unrelated research project. Dr. Bea also serves as a consultant for the WHI Western Region and as a reviewer for the WHI Papers and Proposals Committee. Dr. Thomson would like to disclose serving as Chair of the WHI Steering Committee. All other authors report no conflicts of interest.

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