Anti-nephrin autoantibodies: a paradigm shift in podocytopathies

Zhao Cui^{1

2}, Ming-Hui Zhao^{3

4}

Affiliations

¹ Renal Division, Peking University First Hospital, Beijing, China.
² Institute of Nephrology, Peking University, Beijing, China.
³ Renal Division, Peking University First Hospital, Beijing, China. mhzhao@bjmu.du.cn.
⁴ Institute of Nephrology, Peking University, Beijing, China. mhzhao@bjmu.du.cn.

Zhao Cui et al. Nat Rev Nephrol. 2024 Oct.

. 2024 Oct;20(10):639-640.

doi: 10.1038/s41581-024-00873-7.

Zhao Cui^{1

2}, Ming-Hui Zhao^{3

4}

¹ Renal Division, Peking University First Hospital, Beijing, China.
² Institute of Nephrology, Peking University, Beijing, China.
³ Renal Division, Peking University First Hospital, Beijing, China. mhzhao@bjmu.du.cn.
⁴ Institute of Nephrology, Peking University, Beijing, China. mhzhao@bjmu.du.cn.

No abstract available

References

1. Iijima, K. et al. Rituximab for childhood-onset, complicated, frequently relapsing nephrotic syndrome or steroid-dependent nephrotic syndrome: a multicentre, double-blind, randomised, placebo-controlled trial. Lancet 384, 1273–1281 (2014). - DOI - PubMed
1. Watts, A. J. B. et al. Discovery of autoantibodies targeting nephrin in minimal change disease supports a novel autoimmune etiology. J. Am. Soc. Nephrol. 33, 238–252 (2022). - DOI - PubMed - PMC
1. Takeuchi, K. et al. New anti-nephrin antibody mediated podocyte injury model using a C57BL/6 mouse strain. Nephron 138, 71–87 (2018). - DOI - PubMed
1. Hengel, F. E. et al. Autoantibodies targeting nephrin in podocytopathies. N. Engl. J. Med. https://doi.org/10.1056/NEJMoa2314471 (2024).
1. Zhang, Y. M. et al. Clinical significance of IgM and C3 glomerular deposition in primary focal segmental glomerulosclerosis. Clin. J. Am. Soc. Nephrol. 11, 1582–1589 (2016). - DOI - PubMed - PMC