Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Sep;76(5):1783-1796.
doi: 10.1007/s13304-024-01945-w. Epub 2024 Jul 30.

Cornerstones and divergencies in the implementation and use of liver hypertrophy techniques: results from a nationwide survey for the set-up of the prospective registry

Francesca Ratti #  1   2 , Matteo Serenari #  3   4 , Alfonso Avolio  5 , Giacomo Batignani  6 , Ugo Boggi  7 , Alberto Brolese  8 , Lucio Caccamo  9 , Andrea Celotti  10 , Umberto Cillo  11 , Nicola Cinardi  12 , Christian Cotsoglou  13 , Raffaele Dalla Valle  14 , Luciano De Carlis  15 , Paolo De Simone  16 , Fabrizio Di Benedetto  17 , Giorgio Ercolani  4   18 , Giuseppe Maria Ettorre  19 , Massimo Fedi  20 , Alessandro Ferrero  21 , Antonio Giuliani  22 , Felice Giuliante  23 , Gian Luca Grazi  6 , Salvatore Gruttadauria  24   25 , Alfredo Guglielmi  26 , Francesco Izzo  27 , Quirino Lai  28 , Dario Lorenzin  29 , Marcello Maestri  30 , Marco Massani  31 , Vincenzo Mazzaferro  32   33 , Riccardo Memeo  34   35 , Bruno Nardo  36 , Nazario Portolani  37 , Matteo Ravaioli  3   4 , Aldo Rocca  38   39 , Renato Romagnoli  40 , Fabrizio Romano  41 , Edoardo Saladino  42 , Giuseppe Tisone  43 , Roberto Troisi  44 , Luigi Veneroni  45 , Giovanni Vennarecci  46 , Luca Viganò  47   48 , Giuseppe Viola  49 , Marco Vivarelli  50 , Giacomo Zanus  51 , Luca Aldrighetti #  52   53 , Elio Jovine #  4   54 ; IGROWtoH (Italian Group of Regenerative, Occlusive Worldwide-used Techniques Of hepatic Hypertrophy) group
Affiliations

Cornerstones and divergencies in the implementation and use of liver hypertrophy techniques: results from a nationwide survey for the set-up of the prospective registry

Francesca Ratti et al. Updates Surg. 2024 Sep.

Abstract

Background: The aim of this national survey on liver hypertrophy techniques was to track the trends of their use and implementation in Italy and to detect analogies and heterogeneities among centers.

Methods: In December 2022, Italian centers with liver resection activity were specifically contacted and asked to fill an online questionnaire composed of 6 sections including a total of 51 questions.

Results: 46 Italian centers filled the questionnaire. The proportion of major/total number of liver resections was 27% and the use of hypertrophy techniques was required in 6,2% of cases. The most frequent reason of drop out was disease progression in 58.5% of cases. Most frequently used techniques were PVE and ALPPS with an increasing use of hepatic venous deprivation (HVD). Heterogeneous answers were provided regarding the cutoff values to indicate the need for hypertrophy techniques. Criteria to allocate a patient to different hypertrophy techniques are not standardized.

Conclusions: The use of hypertrophy techniques is deep-rooted in Italy, documenting the established value of their role in improving resectability rate. While an evolution of techniques is detectable, still significant heterogeneity is perceived in terms of cutoff values, indications and managing protocols.

Keywords: Hypertrophy techniques; Liver failure; Liver surgery; Morbidity; Survey.

PubMed Disclaimer

References

    1. Torzilli G, Serenari M, Viganò L, Cimino M, Benini C, Massani M, Ettorre GM, Cescon M, Ferrero A, Cillo U, Aldrighetti L, Jovine E (2019) Outcomes of enhanced one-stage ultrasound-guided hepatectomy for bilobar colorectal liver metastases compared to those of ALPPS: a multicenter case-match analysis. HPB (Oxford) 21(10):1411–1418. https://doi.org/10.1016/j.hpb.2019.04.001 . (Epub 2019 May 9 PMID: 31078424) - DOI
    1. Ratti F, Cipriani F, Fiorentini G, Burgio V, Ronzoni M, Della Corte A, Cascinu S, De Cobelli F, Aldrighetti L (2021) Evolution of surgical treatment of colorectal liver metastases in the real world: single center experience in 1212 cases. Cancers (Basel) 13(5):1178. https://doi.org/10.3390/cancers13051178.PMID:33803257;PMCID:PMC7967178 - DOI
    1. Ignatavicius P, Oberkofler CE, Chapman WC, DeMatteo RP, Clary BM, D’Angelica MI, Tanabe KK, Hong JC, Aloia TA, Pawlik TM, Hernandez-Alejandro R, Shah SA, Vauthey JN, Torzilli G, Lang H, Line PD, Soubrane O, Pinto-Marques H, Robles-Campos R, Boudjema K, Lodge P, Adam R, Toso C, Serrablo A, Aldrighetti L, DeOliveira ML, Dutkowski P, Petrowsky H, Linecker M, Reiner CS, Braun J, Alikhanov R, Barauskas G, Chan ACY, Dong J, Kokudo N, Yamamoto M, Kang KJ, Fong Y, Rela M, De Aretxabala X, De Santibañes E, Mercado MÁ, Andriani OC, Torres OJM, Pinna AD, Clavien PA (2020) Choices of therapeutic strategies for colorectal liver metastases among expert liver surgeons: a throw of the dice? Ann Surg 272(5):715–722. https://doi.org/10.1097/SLA.0000000000004331 . (PMID: 32833764) - DOI
    1. Vennarecci G, Grazi GL, Sperduti I, Busi Rizzi E, Felli E, Antonini M, D’Offizi G, Ettorre GM (2016) ALPPS for primary and secondary liver tumors. Int J Surg 30:38–44. https://doi.org/10.1016/j.ijsu.2016.04.031 . (Epub 2016 Apr 22 PMID: 27112834) - DOI
    1. Viganò L, Torzilli G, Aldrighetti L, Ferrero A, Troisi R, Figueras J, Cherqui D, Adam R, Kokudo N, Hasegawa K, Guglielmi A, Majno P, Toso C, Krawczyk M, Abu Hilal M, Pinna AD, Cescon M, Giuliante F, de Santibanes E, Costa-Maia J, Pawlik T, Urbani L, Zugna D, CLISCO group (2020) Stratification of major hepatectomies according to their outcome: analysis of 2212 consecutive open resections in patients without cirrhosis. Ann Surg 272(5):827–833. https://doi.org/10.1097/SLA.0000000000004338 - DOI

LinkOut - more resources