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Review
. 2024 Jul 30;316(8):496.
doi: 10.1007/s00403-024-03229-0.

A review of TEC family kinases and their inhibitors in the treatment of alopecia areata

Yinglin An #  1 , Fan Zhang #  2
Affiliations
Review

A review of TEC family kinases and their inhibitors in the treatment of alopecia areata

Yinglin An et al. Arch Dermatol Res. .

Abstract

The TEC (tyrosine kinase expressed in hepatocellular carcinoma) family kinases, an important class of protein kinases, play key roles in cell signaling and immune regulation. In this review, the association between the pathogenesis of alopecia areata and the structure and regulatory mechanisms of TEC family kinases in normal physiological processes, is explored. Furthermore, the potential clinical applications of TEC kinases and their inhibitors are highlighted by summarizing current insights into their mechanisms of action, clinical applications, and recent advancements in TEC kinase inhibitor research.

Keywords: Alopecia areata; BTK; ITK; TEC family kinases; TEC kinase inhibitors.

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References

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