Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jul 30;23(1):233.
doi: 10.1186/s12944-024-02193-y.

The uric acid/HDL-C ratio may predict significant coronary stenosis in moderate left main coronary artery lesions: an intravascular ultrasonography study

Ömer Furkan Demir  1 , Abdulsamet Arslan  2 , Mustafa Kınık  3 , Barış Şensoy  2 , Günseli Demir  4
Affiliations

The uric acid/HDL-C ratio may predict significant coronary stenosis in moderate left main coronary artery lesions: an intravascular ultrasonography study

Ömer Furkan Demir et al. Lipids Health Dis. .

Erratum in

Abstract

Background: There may be severe difficulties in determining the severity of LMCA (left main coronary artery) lesions. The use of intravascular ultrasound (IVUS) facilitates decisions about lesion severity in these patients. The aim of this study was to investigate the relationship between the UHR (uric acid to HDL-C ratio) and lesion severity in patients who underwent LMCA IVUS.

Methods: This study included 205 patients with ICS (intermediate coronary stenosis) in the LMCA who underwent IVUS. In the IVUS measurements of these patients, the plaque burden (PB) and the minimal lumen area (MLA) showing lesion severity were measured.

Results: The patients were separated into two groups according to plaque burden (< 65% and ≥ 65%). The UHR was significantly greater in the high plaque burden group (479.5 vs. 428.6, P = 0.001). When the patients were separated into two groups according to the MLA (< 6mm2 and ≥ 6mm2), the UHR was determined to be significantly greater in the group with low MLA (476.8 vs. 414.9, P < 0.001). In the ROC analysis performed according to the MLA and plaque burden values, the UHR cutoff value of 450 was found to have similar sensitivity and the same specificity for both parameters.

Conclusions: The results of this study suggested that there is a relationship between UHR and MLA < 6mm2 and plaque burden ≥ 65%, which are independently evaluated as critical in IVUS, and this could predict anatomically significant lesions in patients with a moderate degree of LMCA stricture.

Keywords: Coronary artery disease; High-density lipoprotein cholesterol; Intravascular ultrasound; Left main coronary artery; Uric acid.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests

Figures

Fig. 1
Fig. 1
Correlations between UHR and atherosclerotic severity variables; (a) correlations between UHR and MLA, (b) correlations between MLA and plaque burden, (c) correlations between plaque burden and UHR
Fig. 2
Fig. 2
ROC curve analysis of the UHR according to minimal lumen area and ROC curve analysis of the UHR according to plaque burden
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. GBD 2013 Mortality and Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the global burden of Disease Study 2013. Lancet. 2015;385(9963):117–71. 10.1016/S0140-6736(14)61682-2 - DOI - PMC - PubMed
    1. Patil CV, Beyar R. Intermediate coronary artery stenosis: evidence-based decisions in interventions to avoid the oculostenotic reflex. Int J Cardiovasc Intervent. 2000;3(4):195–206. 10.1080/14628840050515948 - DOI - PubMed
    1. Patel MR, Peterson ED, Dai D, Brennan JM, Redberg RF, Anderson HV et al. (2010) Low diagnostic yield of elective coronary angiography. N Engl J Med 11;362(10):886 – 95. - PMC - PubMed
    1. Sibbald M, Chan W, Daly P, Horlick E, Ing D, Ivanov J, et al. Long-term outcome of unprotected left main stenting: a Canadian tertiary care experience. Can J Cardiol. 2014;30(11):1407–14. 10.1016/j.cjca.2014.05.023 - DOI - PubMed
    1. Erdoğan M, Erdöl MA, Öztürk S, Durmaz T. Systemic immune-inflammation index is a novel marker to predict functionally significant coronary artery stenosis. Biomark Med. 2020;14(16):1553–61. 10.2217/bmm-2020-0274 - DOI - PubMed

MeSH terms

LinkOut - more resources