From data to practice: brain meningioma treatment in elderly patients - a survey of the Italian Society of Neurosurgery (SINch®) and systematic review and meta-analysis

Abstract

The management of meningioma in elderly patients (MEP) presents a complex and evolving challenge. Data available offer conflicting information on treatment options and complications. This survey aimed to examine the current approach to MEP, comparing the national profile to data in the current literature. A survey addressing the treatments options and management of meningioma in elderly was designed on behalf of SINch® (Società Italiana di Neurochirurgia) and sent via email to all Chiefs of Neurosurgical Departments. The survey remained open for responses from May 5th, 2022, until November 21st, 2022. A search of the literature published between January 2000 and March 2023, in accordance to PRISMA guidelines, was included. A total of 51 Neurosurgical centers participated in the survey. The caseload profile of each center influences the choice of treatment selection (Stereotactic Radiosurgery versus open surgery) (p = 0.01) and the consolidated practice of discussing cases within a multidisciplinary group (p = 0.02). The pooled meta-analysis demonstrated a significant increased risk in the elderly group for permanent deficits (p < 0.00001), postoperative infections (p = 0.0004) and hemorrhage (p = 0.0001), perioperative mortality (p < 0.00001), and medical complications (p < 0.00001) as compared to the young population. This study presents the initial comprehensive analysis of the existing trends in the surgical management of MEP in Italy. The significant variation in practices primarily stems from the absence of standardized guidelines. While most centers have adopted an integrated approach, there is a need to promote a multidisciplinary care model. Prospective studies are needed to gather robust evidence in this clinical setting.

Keywords: Aging; Elderly; Meningioma; Morbidity; Mortality; Outcome; Radiosurgery; Surgery.

Fig. 1

PRIMA flowchart. *The following filters were applied directly to the main search query: only English, no reviews and case reports. Only studies with a clinical application in patients were eligible, Study range was set between 2000 and 2023. ** The first number refers to records identified via keywords, the second refers to records identified via MeSH. ***The first number refers to records identified via keywords, the second refers to records identified via Emtree

Fig. 2

Forest plot and funnel plot for neurological deficits (A, B), seizure onset (C, D), CSF leakage (E, F), infections (G, H), Hemorrhage (I, J), medical complications (K, L) and mortality (M, N)