Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jul;25(4):e58.
doi: 10.4142/jvs.24118.

Pharmacokinetics of oxytetracycline in hybrid catfish (Clarias macrocephalus x C. gariepinus) after intravascular and oral administrations

Amnart Poapolathep  1 , Kednapat Sriphairoj  2 , Sittichai Hatachote  2 , Kannika Wongpanit  2 , Duangkamol Saensawath  2 , Narumol Klangkaew  1 , Napasorn Phaochoosak  1 , Mario Giorgi  3 , Saranya Poapolathep  4
Affiliations

Pharmacokinetics of oxytetracycline in hybrid catfish (Clarias macrocephalus x C. gariepinus) after intravascular and oral administrations

Amnart Poapolathep et al. J Vet Sci. 2024 Jul.

Abstract

Importance: Over the past decade, catfish farming has increased in Southeast Asia. However, there has been no existing for pharmacokinetic data in the hybrid catfish (Clarias macrocephalus x C. gariepinus).

Objective: This study was designed to evaluate the pharmacokinetic characteristics of oxytetracycline (OTC) in the hybrid catfish, following single intravascular (IV) or oral (PO) administration at a single dosage of 50 mg/kg body weight (BW).

Methods: In total, 140 catfish (each about 100-120 g BW) were divided into two groups (n = 70). Blood samples (0.6-0.8 mL) were collected from ventral caudal vein at pre-assigned times up to 144 h (sparse samples design). OTC plasma concentrations were analyzed using high-performance liquid chromatography-photodiode array detector.

Results: The pharmacokinetic parameter of OTC was evaluated using a non-compartment model. OTC plasma concentrations were detectable for up to 144 and 120 h after IV and PO, respectively. The elimination half-life value of OTC was long with slow clearance after IV administration in hybrid catfish. The average maximum concentration value of OTC was 2.72 µg/mL with a time at the maximum concentration of 8 h. The absolute PO bioavailability was low (2.47%).

Conclusions and relevance: These results showed that PO administration of OTC at a dosage of 50 mg/kg BW was unlikely to be effective for clinical use in catfish. The pharmacodynamic properties and clinical efficacy of OTC after multiple medicated feed are warranted.

Keywords: Oxytetracycline; animal feed; catfish; oxytetracycline; pharmacokinetics.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Fig. 1
Fig. 1. Mean values (± SD) of oxytetracycline concentration in plasma of hybrid catfish (Clarias macrocephalus x C. gariepinus) after IV and PO administrations at dosage of 50 mg/kg body weight. Each fish was sampled once and each time point had 5 blood collections.
IV, intravascular; PO, oral.
See this image and copyright information in PMC

References

    1. Na-Nakorn U, Brummett RE. Use and exchange of aquatic genetic resources for food and aquaculture: Clarias catfish. Rev Aquacult. 2009;1:214–223.
    1. Nukwan S, Tangtrongpiros M, Lawanyawut K, Veerasidth P. Hybridization between Clarias macrocephalus and Clarias gariepinus; Proceedings of the 28th Kasetsart University Conference; Bangkok: Kasetsart University Press; 1990. pp. 553–568.
    1. Department of Fisheries (TH) Fisheries Statistics of Thailand 2022. Technical Paper No. 12/2023. Bangkok: Ministry of Agriculture and Cooperatives; 2023.
    1. Swangdacharuk G, Musig Y. Growth, production, feed conversion ratio, water quality and nutrient budget of hybrid catfish (Clarias macrocephalus x C. gariepinus) cultivation in earthen ponds without water exchange. Fish Res Bull Kasetsart Univ. 2016;40:78–92.
    1. Rigos G, Smith PA. Critical approach on pharmacokinetics, pharmacodynamics, dose optimisation and withdrawal times of oxytetracycline in aquaculture. Rev Aquacult. 2015;7:77–106.

MeSH terms

LinkOut - more resources