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Meta-Analysis
. 2024 Jul 31;19(7):e0307942.
doi: 10.1371/journal.pone.0307942. eCollection 2024.

Effects of short inter-pregnancy/birth interval on adverse perinatal outcomes in Asia-Pacific region: A systematic review and meta-analysis

Tahir Ahmed Hassen  1   2 , Melissa L Harris  2 , Desalegn Markos Shifti  2   3 , Tesfalidet Beyene  2 , Md Nuruzzaman Khan  4 , Tesfaye Regassa Feyissa  5 , Catherine Chojenta  6
Affiliations
Meta-Analysis

Effects of short inter-pregnancy/birth interval on adverse perinatal outcomes in Asia-Pacific region: A systematic review and meta-analysis

Tahir Ahmed Hassen et al. PLoS One. .

Abstract

Background: Short inter-pregnancy or birth interval is associated with an increased risk of adverse perinatal outcomes. However, some emerging evidence questions this association and there are also inconsistencies among the existing findings. This study aimed to systematically review the evidence regarding the effect of short inter-pregnancy or birth intervals on adverse perinatal outcomes in the Asia-Pacific region.

Methods: A comprehensive search of five databases was conducted targeting studies published between 2000 to 2023. Studies that reported on short inter-pregnancy or birth interval and examined adverse perinatal outcomes, such as low birthweight (LBW) preterm birth (PTB), small for gestational age (SGA), and neonatal mortality were included and appraised for methodological quality using the Joanna Briggs Institute critical appraisal tools. Three reviewers independently screened the studies and performed data extraction. Narrative synthesis and meta-analyses were conducted to summarise the key findings.

Results: A total of 41 studies that fulfilled the inclusion criteria were included. A short-interpregnancy interval was associated with an increased risk of low birthweight (odds ratio [OR] = 1.65; 95%CI:1.39, 1.95), preterm birth (OR = 1.50; 95%CI: 1.35, 1.66), and small for gestational age (OR = 1.24; 95%CI:1.09, 1.41). We also found elevated odds of early neonatal mortality (OR = 1.91; 95%CI: 1.11, 3.29) and neonatal mortality (OR = 1.78; 95%CI: 1.25, 2.55) among women with short birth intervals.

Conclusion: This review indicates that both short inter-pregnancy and birth interval increased the risk of adverse perinatal outcomes. This underscores the importance of advocating for and implementing strategies to promote optimal pregnancy and birth spacing to reduce the occurrence of adverse perinatal outcomes. Reproductive health policies and programs need to be further strengthened and promote access to comprehensive family planning services and increase awareness about the importance of optimal pregnancy and birth spacing.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Studies selection process according to PRISMA 2020 statement.
See this image and copyright information in PMC

References

    1. Zhu BP. Effect of interpregnancy interval on birth outcomes: findings from three recent US studies. International Journal of Gynecology & Obstetrics. 2005;89:S25–S33. doi: 10.1016/j.ijgo.2004.08.002 - DOI - PubMed
    1. Shachar BZ, Lyell DJ. Interpregnancy interval and obstetrical complications. Obstetrical & gynecological survey. 2012;67(9):584–96. doi: 10.1097/OGX.0b013e31826b2c3e - DOI - PubMed
    1. World Health Organization. Report of a WHO technical consultation on birth spacing: Geneva, Switzerland 13–15 June 2005. World Health Organization, 2007.
    1. Exavery A, Mrema S, Shamte A, Bietsch K, Mosha D, Mbaruku G, et al.. Levels and correlates of non-adherence to WHO recommended inter-birth intervals in Rufiji, Tanzania. BMC pregnancy and childbirth. 2012;12:1–8. - PMC - PubMed
    1. De Jonge HC, Azad K, Seward N, Kuddus A, Shaha S, Beard J, et al.. Determinants and consequences of short birth interval in rural Bangladesh: a cross-sectional study. BMC pregnancy and childbirth. 2014;14(1):1–7. doi: 10.1186/s12884-014-0427-6 - DOI - PMC - PubMed

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