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. 2024 Oct 25:140:112763.
doi: 10.1016/j.intimp.2024.112763. Epub 2024 Jul 30.

Secretory Nogo-B regulates Th2 differentiation in the lung cancer microenvironment

Changfei Qin  1 , Wenxia Li  1 , Yi Zhang  2 , Zhaojun Wang  3 , Yang Leng  3 , Jingyun Ma  2 , Chao Qin  2 , Shumin Cheng  2 , Ling Xue  4 , Kuangyu Song  5 , Bihui Huang  6
Affiliations

Secretory Nogo-B regulates Th2 differentiation in the lung cancer microenvironment

Changfei Qin et al. Int Immunopharmacol. .

Erratum in

Abstract

Nogo-B, a ubiquitously expressed member of the reticulon family, plays an important role in maintaining endoplasmic reticulum (ER) structure, regulating protein folding, and calcium homeostasis. In this study, we demonstrate that Nogo-B expression and secretion are upregulated in lung cancer and correlate to overall survival. Nogo-B is secreted by various cells, particularly lung cancer cells. ER stress and phosphorylation at serine 107 can induce Nogo-B secretion. Secretory Nogo-B suppresses the differentiation of Th2 cells and the release of type 2 cytokines, thus influencing the anti-tumor effects of Th2-related immune cells, including IgE+B cell class switching and eosinophil activation.

Keywords: Endoplasmic reticulum stress; Lung cancer; Nogo-B; Secretion; Th2 cell.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.