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. 2024 Sep;30(9):1903-1906.
doi: 10.3201/eid3009.240557. Epub 2024 Jul 31.

Emergence of Extensively Drug-Resistant Neisseria gonorrhoeae, France, 2023

François Caméléna, Manel Mérimèche, Julie Brousseau, Mary Mainardis, Pascale Verger, Caroll Le Risbé, Elise Brottet, Alexandra Thabuis, Cécile Bébéar, Jean-Michel Molina, Florence Lot, Emilie Chazelle, Béatrice Berçot

Emergence of Extensively Drug-Resistant Neisseria gonorrhoeae, France, 2023

François Caméléna et al. Emerg Infect Dis. 2024 Sep.

Abstract

Since 2022, Europe has had 4 cases of extensively drug-resistant Neisseria gonorrhoeae, sequence type 16406, that is resistant to ceftriaxone and highly resistant to azithromycin. We report 2 new cases from France in 2023 involving strains genetically related to the 4 cases from Europe as well as isolates from Cambodia.

Keywords: A2059G mutation; Azithromycin; Ceftriaxone; Drug-resistant; France; Neisseria gonorrhoeae; ST16406; antimicrobial resistance; bacteria; gonorrhea; penA-60.001; sexually transmitted infections; surveillance.

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Figures

Figure
Figure
Phylogenetic tree of 19 Neisseria gonorrhoeae isolates, including 2 from patients in France, compared on the basis of their main resistance determinants. The phylogenetic tree was built from 10,907 total core single-nucleotide polymorphism positions. The F95 and F96 isolates from 2 patients in France were compared with ceftriaxone-resistant and extensively drug-resistant N. gonorrhoeae isolates from Europe, Australia, Cambodia, Japan, and the United States. The tree is rooted on N. gonorrheae FA1090, a laboratory reference strain. Scale bar indicates the branch length corresponding to genetic change.
See this image and copyright information in PMC

References

    1. Unemo M, Lahra MM, Escher M, Eremin S, Cole MJ, Galarza P, et al. WHO global antimicrobial resistance surveillance for Neisseria gonorrhoeae 2017-18: a retrospective observational study. Lancet Microbe. 2021;2:e627–36. 10.1016/S2666-5247(21)00171-3 - DOI - PubMed
    1. Pleininger S, Indra A, Golparian D, Heger F, Schindler S, Jacobsson S, et al. Extensively drug-resistant (XDR) Neisseria gonorrhoeae causing possible gonorrhoea treatment failure with ceftriaxone plus azithromycin in Austria, April 2022. Euro Surveill. 2022;27:1–5. 10.2807/1560-7917.ES.2022.27.24.2200455 - DOI - PMC - PubMed
    1. Day M, Pitt R, Mody N, Saunders J, Rai R, Nori A, et al. Detection of 10 cases of ceftriaxone-resistant Neisseria gonorrhoeae in the United Kingdom, December 2021 to June 2022. Euro Surveill. 2022;27:2200803. 10.2807/1560-7917.ES.2022.27.46.2200803 - DOI - PMC - PubMed
    1. Maubaret C, Caméléna F, Mrimèche M, Braille A, Liberge M, Mainardis M, et al. Two cases of extensively drug-resistant (XDR) Neisseria gonorrhoeae infection combining ceftriaxone-resistance and high-level azithromycin resistance, France, November 2022 and May 2023. Euro Surveill. 2023;28:1–5. 10.2807/1560-7917.ES.2023.28.37.2300456 - DOI - PMC - PubMed
    1. Ouk V, Pham CD, Wi T, van Hal SJ, Lahra MM; EGASP Cambodia working group. EGASP Cambodia working group. The enhanced gonococcal surveillance programme, Cambodia. Lancet Infect Dis. 2023;23:e332–3. 10.1016/S1473-3099(23)00479-6 - DOI - PubMed

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