Percutaneous Neuromodulation for Atrial Fibrillation

Abstract

Percutaneous neuromodulation is emerging as a promising therapeutic approach for atrial fibrillation (AF). This article explores techniques such as ganglionated plexi (GP) ablation, and vagus nerve stimulation, pinpointing their potential in modulating AF triggers and maintenance. Noninvasive methods, such as transcutaneous low-level tragus stimulation, offer innovative treatment pathways, with early trials indicating a significant reduction in AF burden. GP ablation may address autonomic triggers, and the potential for GP ablation in neuromodulation is discussed. The article stresses the necessity for more rigorous clinical trials to validate the safety, reproducibility, and efficacy of these neuromodulation techniques in AF treatment.

Keywords: Atrial fibrillation; Autonomic modulation; Ganglionated plexi ablation; Percutaneous neuromodulation; Pulmonary vein isolation; Renal denervation; Transcutaneous low-level tragus stimulation; Vagus nerve stimulation.