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. 2024 Sep;26(6):595-603.
doi: 10.1111/bdi.13480. Epub 2024 Jul 31.

Does BioAge identify accelerated aging in individuals with bipolar disorder? An exploratory study in the FACE-BD cohort

Bruno Etain  1   2   3 , Cynthia Marie-Claire  1 , Luana Spano  1 , Frank Bellivier  1   2   3 , Marion Leboyer  3   4   5 , Sébastien Gard  3   6 , Antoine Lefrere  3   7 , Raoul Belzeaux  3   8 , Philippe Courtet  3   9 , Caroline Dubertret  3   10   11 , Raymund Schwan  3   12 , Valerie Aubin  3   13 , Paul Roux  3   14   15 , Mircea Polosan  3   16 , Ludovic Samalin  3   17 , Emmanuel Haffen  3   18 , Emilie Olié  3   9 , Ophelia Godin  3   4 ; FondaMental Advanced Centers of Expertise in Bipolar Disorders (FACE‐BD) Collaborators  3
Collaborators, Affiliations

Does BioAge identify accelerated aging in individuals with bipolar disorder? An exploratory study in the FACE-BD cohort

Bruno Etain et al. Bipolar Disord. 2024 Sep.

Abstract

Background: Individuals with bipolar disorders (BD) have an estimated loss of life expectancy around 10-15 years. Several laboratory-measured biomarkers of accelerated aging exist (e.g., telomere length), however with a questionable transferability to bedside. There is a need for easily and inexpensively measurable markers of aging, usable in routine practice, such as BioAge.

Methods: We calculated BioAge that estimates biological age based on routine blood tests and a physical exam, in a sample of 2220 outpatients with BD. We investigated associations between BioAge Acceleration (BioAgeAccel), which is an indicator of accelerated aging, and sociodemographic variables, clinical variables, and current psychotropic medication use.

Results: Mean chronological age was 40.2 (±12.9). Mean BioAge was 39.1 (±12.4). Mean BioAgeAccel was 0.08 (±1.8). A minority of individuals (15%) had a BioAgeAccel above 2 years. Multivariable analyses suggested strong associations between a higher BioAgeAccel and younger age, male sex, overweight and sleep disturbances. Regarding current psychotropic medication use, discrepancies between univariate and multivariate analyses were observed.

Conclusions: A minority of individuals with BD had an accelerated aging as measured by BioAge. We identified associations with potentially modifiable factors, such as higher body mass index and sleep disturbances, that are however nonspecific to BD. These results require replications in independent samples of individuals with BD, and comparisons with a control group matched for age and gender. Longitudinal studies are also required to test whether any change in metabolic health, or sleep might decrease BioAgeAccel.

Keywords: accelerated aging; bioage; biological age; bipolar disorder; determinants; medications; obesity; sleep.

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References

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