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Randomized Controlled Trial
. 2024 Oct;63(7):2789-2799.
doi: 10.1007/s00394-024-03464-1. Epub 2024 Jul 31.

Effect of whey protein-derived decapeptide on mood status and blood variables in healthy adults: a randomized, double-blind, placebo-controlled cross-over trial

Katsuya Suzuki  1 , Yoriko Okamatsu  2 , Ryo Uchida  2 , Ikuko Sasahara  2 , Masamichi Takeshita  3 , Wataru Sato  3 , Yoshiro Kitahara  2 , Hitoshi Murakami  2
Affiliations
Randomized Controlled Trial

Effect of whey protein-derived decapeptide on mood status and blood variables in healthy adults: a randomized, double-blind, placebo-controlled cross-over trial

Katsuya Suzuki et al. Eur J Nutr. 2024 Oct.

Retraction in

Abstract

Purpose: The importance of maintaining good mental health with overall well-being has recently drawn attention from various fields. Functional peptides found from various protein sources reportedly reduce mental health problems. We found a new decapeptide (AJI-801) from whey proteins, which can possibly improve mood status and increase blood acetyl-L-carnitine (ALC) and fibroblast growth factor 21 (FGF21) levels. In this study, we assessed the effects of a single intake of whey protein hydrolysate containing a high amount of AJI-801 (WPH) on blood variables and mood status.

Methods: A randomized, double-blind, placebo-controlled cross-over trial of two doses of WPH (100 and 500 mg) was conducted. Participants, aged between 20 and 59 years with fatigue were allocated to two groups based on the WPH doses received, and set first test food in each study. The blood ALC and FGF21 levels at baseline and after 60, 120, and 180 min of test food intake were analyzed and the responses to the questionnaire items for mood status were obtained at baseline and after 60 and 180 min of test food intake.

Results: There were no significant differences in the blood ALC and FGF21 levels between the two groups. As mood status, intake of 500-mg WPH (including 2.5-mg AJI-801) showed significant improvement in Depression/Dejection of the Profile of Mood States Questionnaire second edition and visual analog scale score for depression, as compared to the placebo.

Conclusions: Intake of AJI-801 500-mg WPH (including 2.5-mg AJI-801) contributes to the improvement of feeling down in healthy persons with fatigue.

Trial registration: University Hospital Medical Information Network Clinical Trial Registry (UMIN 000046829).

Keywords: Feeling down; Healthy persons with fatigue; Mental health; Whey peptide.

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Conflict of interest statement

This study was supported by Ajinomoto Co., Inc. All authors are employees of Ajinomoco Co., Inc. All authors declare that the findings of the present study are presented clearly, honestly and without fabrication, falsification, or inappropriate data manipulation.

Figures

Fig. 1
Fig. 1
The outline of the present study A Cross-over study schedule. B The details of the treatment schedule
Fig. 2
Fig. 2
The study flow diagram. WPH: whey protein hydrolysate containing a high amount of AJI-801
See this image and copyright information in PMC

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