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Review
. 2024 Nov;54(11):e2350496.
doi: 10.1002/eji.202350496. Epub 2024 Jul 31.

Diversity of regulatory B cells: Markers and functions

Hannah F Bradford  1 , Claudia Mauri  1
Affiliations
Free article
Review

Diversity of regulatory B cells: Markers and functions

Hannah F Bradford et al. Eur J Immunol. 2024 Nov.
Free article

Abstract

Regulatory B cells (Bregs) are a functionally distinct B-cell subset involved in the maintenance of homeostasis and inhibition of inflammation. Studies, from the last two decades, have increased our understanding of cellular and molecular mechanisms involved in their generation, function, and to a certain extent phenotype. Current research endeavours to unravel the causes and consequences of Breg defects in disease, with increasing evidence highlighting the relevance of Bregs in promoting tumorigenic responses. Here we provide historical and emerging findings of the significance of Bregs in autoimmunity and transplantation, and how these insights have translated into the cancer field.

Keywords: Autoimmunity; B cells; Breg; Cancer; Cellular immunology; Immune regulation; Regulatory B cell.

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