Ponatinib alone or with chemo-immunotherapy in heavily pre treated Philadelphia-like acute lymphoblastic leukemia: a CAMPUS ALL real-life study

Affiliations

¹ Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome.
² Division of Hematology, Department of Translational Medicine, AOU Maggiore della Carità, Università del Piemonte Orientale, Novara.
³ Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy; AIL ROMA ODV, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome.
⁴ Hematology Department, ASST Settelaghi, Ospedale di Circolo - Fondazione Macchi, Varese.
⁵ Hematology Department, Azienda Ospedaliera Universitaria Senese, Siena.
⁶ San Raffaele Scientific Institute, Department of Onco-Hematology, Milan.
⁷ Division of Hematology and SCT, Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), University Hospital of Udine.
⁸ Hematology Department, Ospedale Civile Pescara.
⁹ Hematology Department, Azienda Ospedaliero-Universitaria Careggi, Florence.
¹⁰ Section of Hematology, Department of Medicine and Surgery, Center for Hemato-Oncological Research (CREO), University of Perugia, Perugia.
¹¹ Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan.
¹² Department of Molecular Biotechnology and Health Sciences, Division of Hematology, University of Torino, Torino.
¹³ Hematology Department, Moscati Hospital, Aversa.
¹⁴ Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome. chiaretti@bce.uniroma1.it.

Francesca Kaiser et al. Haematologica. 2024.

. 2024 Dec 1;109(12):4095-4099.

doi: 10.3324/haematol.2024.285258.

¹ Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome.
² Division of Hematology, Department of Translational Medicine, AOU Maggiore della Carità, Università del Piemonte Orientale, Novara.
³ Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy; AIL ROMA ODV, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome.
⁴ Hematology Department, ASST Settelaghi, Ospedale di Circolo - Fondazione Macchi, Varese.
⁵ Hematology Department, Azienda Ospedaliera Universitaria Senese, Siena.
⁶ San Raffaele Scientific Institute, Department of Onco-Hematology, Milan.
⁷ Division of Hematology and SCT, Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), University Hospital of Udine.
⁸ Hematology Department, Ospedale Civile Pescara.
⁹ Hematology Department, Azienda Ospedaliero-Universitaria Careggi, Florence.
¹⁰ Section of Hematology, Department of Medicine and Surgery, Center for Hemato-Oncological Research (CREO), University of Perugia, Perugia.
¹¹ Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan.
¹² Department of Molecular Biotechnology and Health Sciences, Division of Hematology, University of Torino, Torino.
¹³ Hematology Department, Moscati Hospital, Aversa.
¹⁴ Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome. chiaretti@bce.uniroma1.it.

No abstract available

Figures

1. Chiaretti S, Li X, Gentleman R, et al. . Gene expression profiles of B-lineage adult acute lymphocytic leukemia reveal genetic patterns that identify lineage derivation and distinct mechanisms of transformation. Clin Cancer Res. 2005;11(20):7209-7219. - PubMed
1. Haferlach T, Kohlmann A, Schnittger S, et al. . Global approach to the diagnosis of leukemia using gene expression profiling. Blood. 2005;106(4):1189-1198. - PubMed
1. Den Boer ML, van Slegtenhorst M, De Menezes RX, et al. . A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study. Lancet Oncol. 2009;10(2):125-1234. - PMC - PubMed
1. Harvey RC, Mullighan CG, Wang X, et al. . Identification of novel cluster groups in pediatric highrisk B precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome. Blood. 2010;116(23):4874-4884. - PMC - PubMed
1. Roberts KG, Gu Z, Payne-Turner D, et al. . High frequency and poor outcome of Philadelphia chromosome-like acute lymphoblastic leukemia in adults. J Clin Oncol. 2017;35(4):394-401. - PMC - PubMed