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Review
. 2023 Jun 6:3:1202190.
doi: 10.3389/fmmed.2023.1202190. eCollection 2023.

Muscle-derived exosomes and exercise in cancer prevention

Affiliations
Review

Muscle-derived exosomes and exercise in cancer prevention

Daniela Vitucci et al. Front Mol Med. .

Abstract

There are a lot of evidences on the beneficial effects mediated by exercise on the prevention of not communicable diseases (NCDs) including different type of cancer. The production of circulating exerkines transported in exosomes represents a novel pathway activated by exercise. However, the biological mechanisms that could explain the role of exosomes in cancer prevention have been not fully elucidated. The aim of this mini-review is to provide an update on the biological mechanisms bringing the release of muscle-derived exosomes during exercise and cancer prevention.

Keywords: cancer; exercise; exerkines; exosomes; tumor microenvironment.

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Conflict of interest statement

Authors DV, AA, and PB were employed by CEINGE-Biotecnologie Avanzate Franco Salvatore. The remaining author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Graphical representation of exercise-induced exosomes released from contracting skeletal muscle.
FIGURE 2
FIGURE 2
Schematic representation of the potential effects of exercise on the regulation of tumor microenvironment.

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