Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jun 6:3:1202190.
doi: 10.3389/fmmed.2023.1202190. eCollection 2023.

Muscle-derived exosomes and exercise in cancer prevention

Daniela Vitucci  1   2 , Domenico Martone  3 , Andreina Alfieri  1   2 , Pasqualina Buono  1   2
Affiliations
Review

Muscle-derived exosomes and exercise in cancer prevention

Daniela Vitucci et al. Front Mol Med. .

Abstract

There are a lot of evidences on the beneficial effects mediated by exercise on the prevention of not communicable diseases (NCDs) including different type of cancer. The production of circulating exerkines transported in exosomes represents a novel pathway activated by exercise. However, the biological mechanisms that could explain the role of exosomes in cancer prevention have been not fully elucidated. The aim of this mini-review is to provide an update on the biological mechanisms bringing the release of muscle-derived exosomes during exercise and cancer prevention.

Keywords: cancer; exercise; exerkines; exosomes; tumor microenvironment.

PubMed Disclaimer

Conflict of interest statement

Authors DV, AA, and PB were employed by CEINGE-Biotecnologie Avanzate Franco Salvatore. The remaining author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Graphical representation of exercise-induced exosomes released from contracting skeletal muscle.
FIGURE 2
FIGURE 2
Schematic representation of the potential effects of exercise on the regulation of tumor microenvironment.
See this image and copyright information in PMC

References

    1. Badouel C., McNeill H. (2011). SnapShot: The Hippo signaling pathway. Cell 145, 484–484.e1. 10.1016/j.cell.2011.04.009 - DOI - PubMed
    1. Benjamin-Davalos S., Koroleva M., Allen C. L., Ernstoff M. S., Shu S. (2021). Co-isolation of cytokines and exosomes: Implications for immunomodulation studies. Front. Immunol. 12, 638111. 10.3389/fimmu.2021.638111 - DOI - PMC - PubMed
    1. Bryant R. J., Pawlowski T., Catto J. W., Marsden G., Vessella R. L., Rhees B., et al. (2012). Changes in circulating microRNA levels associated with prostate cancer. Br. J. Cancer 106, 768–774. 10.1038/bjc.2011.595 - DOI - PMC - PubMed
    1. Campanella C., Bucchieri F., Ardizzone N. M., Marino Gammazza A., Montalbano A., Ribbene A., et al. (2008). Upon oxidative stress, the antiapoptotic Hsp60/procaspase-3 complex persists in mucoepidermoid carcinoma cells. Eur. J. Histochem. 52, 221–228. 10.4081/1220 - DOI - PubMed
    1. Cevenini A., Orrù S., Mancini A., Alfieri A., Buono P., Imperlini E. (2018). Molecular signatures of the insulin-like growth factor 1-mediated epithelial-mesenchymal transition in breast, lung and gastric cancers. Int. J. Mol. Sci. 19 (8), 2411. 10.3390/ijms19082411 - DOI - PMC - PubMed

LinkOut - more resources