Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Aug 1;134(15):e184205.
doi: 10.1172/JCI184205.

A half-century of VEGFA: from theory to practice

Affiliations

A half-century of VEGFA: from theory to practice

Susan E Quaggin. J Clin Invest. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: SEQ holds patents related to therapeutic targeting of the ANGPT/TEK pathway in ocular hypertension and glaucoma (patent nos. ZA202204983B, 9719135, WO2017190222A1,US20160000871A1, CA3168534A1, WO2021173999A1, US20230103583A1). SEQ also receives consulting fees from AstraZeneca, Janssen, and Roche/Genentech; is a scientific advisor for AstraZeneca, Genentech/Roche, Merck, UNITY, Novartis, and Pfizer; and is on the board of directors of Abbvie.

References

    1. Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med. 1971;285(21):1182–1186. doi: 10.1056/NEJM197111182852108. - DOI - PubMed
    1. Dvorak HF, et al. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol. 1995;146(5):1029–1039. - PMC - PubMed
    1. Senger DR, et al. A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines. Cancer Res. 1986;46(11):5629–5632. - PubMed
    1. Senger DR, et al. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science. 1983;219(4587):983–985. doi: 10.1126/science.6823562. - DOI - PubMed
    1. Connolly DT, et al. Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. J Clin Invest. 1989;84(5):1470–1478. doi: 10.1172/JCI114322. - DOI - PMC - PubMed

Publication types

Substances