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Meta-Analysis
. 2024 Jul;39(7):701-714.
doi: 10.1007/s10654-024-01144-2. Epub 2024 Aug 1.

Incidence and prevalence of Alzheimer's disease in China: a systematic review and meta-analysis

Qianqian Ji  1 , Jingqi Chen  2 , Yafei Li  2 , Enxiang Tao  3 , Yiqiang Zhan  4
Affiliations
Meta-Analysis

Incidence and prevalence of Alzheimer's disease in China: a systematic review and meta-analysis

Qianqian Ji et al. Eur J Epidemiol. 2024 Jul.

Abstract

As China faces demographic shifts and socioeconomic changes, the burden of Alzheimer's disease (AD) and associated cognitive impairments is increasing dramatically, with significant implications for public health and the economy. This systematic review and meta-analysis aims to provide a comprehensive assessment of the prevalence and incidence of AD across China. Drawing from an extensive search of international and Chinese databases up to August 27, 2023, including PubMed, Embase, and the Cochrane Library, we synthesized data from 105 studies. Our analysis reveals a combined prevalence of AD of 3.48% within a sample of 626,276 elderly individuals and an incidence rate of 7.90 per 1000 person-years. Subgroup and meta-regression analyses highlight age and gender as pivotal factors influencing these epidemiological patterns. Notably, significant heterogeneity exists due to variations in diagnostic criteria and study quality, impacting the comparability of findings. This meta-analysis underscores the need for continued research into demographic and modifiable risk factors influencing AD, while emphasizing standardized reporting practices to address these limitations and improve the understanding of AD's challenge in China.

Keywords: Alzheimer’s disease; Incidence; Meta-analysis; Prevalence.

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References

    1. Breijyeh Z, Karaman R. Comprehensive review on alzheimer’s disease: causes and treatment. Molecules (Basel, Switzerland). 2020;25(24):5789. https://doi.org/10.3390/molecules25245789 . - DOI - PubMed
    1. Lambert MA, Bickel H, Prince M, Fratiglioni L, Von Strauss E, Frydecka D, et al. Estimating the burden of early onset dementia; systematic review of disease prevalence. Eur J Neurol. 2014;21(4):563–9. https://doi.org/10.1111/ene.12325 . - DOI - PubMed
    1. Dubois B, Feldman HH, Jacova C, Hampel H, Molinuevo JL, Blennow K, et al. Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria. Lancet Neurol. 2014;13(6):614–29. https://doi.org/10.1016/S1474-4422(14)70090-0 . - DOI - PubMed
    1. Livingston G, Sommerlad A, Orgeta V, Costafreda SG, Huntley J, Ames D, et al. Dementia prevention, intervention, and care. Lancet (London, England). 2017;390(10113):2673–734. https://doi.org/10.1016/S0140-6736(17)31363-6 . - DOI - PubMed
    1. Wang Q-H, Wang X, Bu X-L, Lian Y, Xiang Y, Luo H-B, et al. Comorbidity burden of dementia: a hospital-based retrospective study from 2003 to 2012 in seven cities in China. Neurosci Bull. 2017;33(6):703–10. https://doi.org/10.1007/s12264-017-0193-3 . - DOI - PubMed - PMC

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