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Observational Study
. 2025 Mar;23(4):555-563.e1.
doi: 10.1016/j.cgh.2024.07.017. Epub 2024 Jul 31.

Prevalence of Endoscopically Curable Low-Risk Cancer Among Large (≥20 mm) Nonpedunculated Polyps in the Right Colon

Julia L Gauci  1 , Anthony Whitfield  2 , Renato Medas  3 , Clarence Kerrison  2 , Francesco Vito Mandarino  1 , David Gibson  4 , Timothy O'Sullivan  2 , Oliver Cronin  2 , Sunil Gupta  2 , Brian Lam  1 , Varan Perananthan  1 , Luke Hourigan  5 , Simon Zanati  4 , Rajvinder Singh  6 , Spiro Raftopoulos  7 , Alan Moss  4 , Gregor Brown  4 , Amir Klein  8 , Lobke Desomer  9 , David J Tate  10 , Steven J Williams  1 , Eric Y Lee  2 , Nicholas Burgess  2 , Michael J Bourke  11
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Observational Study

Prevalence of Endoscopically Curable Low-Risk Cancer Among Large (≥20 mm) Nonpedunculated Polyps in the Right Colon

Julia L Gauci et al. Clin Gastroenterol Hepatol. 2025 Mar.

Abstract

Background and aims: Endoscopic submucosal dissection is increasingly promoted for the treatment of all large nonpedunculated colorectal polyps (LNPCPs) to cure potential low-risk cancers (superficial submucosal invasion without additional high-risk histopathologic features). The effect of a universal en bloc strategy on oncologic outcomes for the treatment of LNPCPs in the right colon is unknown. We evaluated this in a large Western population.

Methods: A prospective cohort of patients referred for endoscopic resection (ER) of LNPCPs was analyzed. Patients found to have cancer after ER and those referred directly to surgery were included. The primary outcome was to determine the proportion of right colon LNPCPs with low-risk cancer.

Results: Over 180 months until June 2023, 3294 sporadic right colon LNPCPs in 2956 patients were referred for ER at 7 sites (median size 30 [interquartile range 22.5-37.5] mm). A total of 63 (2.1%) patients were referred directly to surgery, and cancer was proven in 56 (88.9%). A total of 2851 (96.4%) of 2956 LNPCPs underwent ER (median size 35 [interquartile range 25-45] mm), of which 75 (2.6%) were cancers. The overall prevalence of cancer in the right colon was 4.4% (n = 131 of 2956). Detailed histopathologic analysis was possible in 115 (88%) of 131 cancers (71 after ER, 44 direct to surgery). After excluding missing histopathologic data, 23 (0.78%) of 2940 sporadic right colon LNPCPs were low-risk cancers.

Conclusions: The proportion of right colon LNPCPs referred for ER containing low-risk cancer amenable to endoscopic cure was <1%, in a large, multicenter Western cohort. A universal endoscopic submucosal dissection strategy for the management of right colon LNPCPs is unlikely to yield improved patient outcomes given the minimal impact on oncologic outcomes.

Clinicaltrials: gov, Numbers: NCT01368289, NCT02000141.

Keywords: Colonoscopy; Colorectal Cancer; Endoscopic Mucosal Resection; Endoscopic Submucosal Dissection; Large Nonpedunculated Colorectal Polyps.

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