Stem Cell Therapy for Wound Healing in Ischemic Limbs: Is It Effective?

Abstract

Critical limb ischemia is an important clinical entity due to its association with increased morbidity and mortality. The mortality and amputation-free survival remains poor especially in those where revascularization is not an option. Recently, the role of cellular therapy has emerged as a promising therapeutic measure that may aid in wound healing and revascularization and improve functional outcomes.

Keywords: Bone marrow-derived cells; Critical limb ischemia; Mesenchymal stem cells; Mononuclear stem cells; Stem cell therapy.