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. 2024 Sep;34(9):698-699.
doi: 10.1016/j.tcb.2024.07.007. Epub 2024 Aug 1.

The ATP-driven extractor ATAD1/Msp1 proof-reads protein translocation into mitochondria

Maria Bohnert  1 , Christos Gatsogiannis  2 , Johannes M Herrmann  3
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Free article

The ATP-driven extractor ATAD1/Msp1 proof-reads protein translocation into mitochondria

Maria Bohnert et al. Trends Cell Biol. 2024 Sep.
Free article

Abstract

The accumulation of translocation intermediates in the mitochondrial import machinery threatens cellular fitness and is associated with cancer and neurodegeneration. A recent study by Weidberg and colleagues identifies ATAD1 as an ATP-driven extraction machine on the mitochondrial surface that pulls precursors into the cytosol to prevent clogging of mitochondrial import pores.

Keywords: AAA protein; cancer; integrated stress response (ISR); mitochondria; protein import; quality control.

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Declaration of interests No interests are declared.

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