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. 2024 Jun;177(2):207-211.
doi: 10.1007/s10517-024-06157-1. Epub 2024 Aug 2.

Effect of Trehalose Disaccharide on Activation of Microglia and Indices of Systemic Inflammation in an Experimental Model of Alzheimer's Disease

S A Zozulya  1 , A A Akopyan  2 , M V Tenditnik  2 , M V Ovsyukova  2 , T A Korolenko  2 , T P Klyushnik  3 , M A Tikhonova  2 , A B Pupyshev  2
Affiliations

Effect of Trehalose Disaccharide on Activation of Microglia and Indices of Systemic Inflammation in an Experimental Model of Alzheimer's Disease

S A Zozulya et al. Bull Exp Biol Med. 2024 Jun.

Abstract

In an experimental model of Alzheimer's disease in mice, oral administration of trehalose disaccharide reduces neuroinflammation assessed by the expression level of microglia activation marker Iba1 and affects the neutrophil degranulation activity. A potential anti-inflammatory effect of 4% trehalose solution associated with a decrease in the activity of leukocyte elastase in plasma was revealed.

Keywords: Alzheimer’s disease; experimental model; leukocyte elastase; microglia; trehalose.

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