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Clinical Trial
. 2024 Oct;205(4):1383-1388.
doi: 10.1111/bjh.19646. Epub 2024 Aug 1.

Long-term efficacy and safety of dose-dense and dose-intense ABVD without consolidation radiotherapy in patients with advanced Hodgkin lymphoma: A 15-year follow-up of the ABVDDD-DI phase II study

Gaetano Corazzelli  1 , Annarosa Cuccaro  1 , Emanuela Morelli  1 , Manuela Arcamone  1 , Annarosaria De Chiara  2 , Andrea Paccone  3 , Antonella Petrillo  4 , Francesco Ibello  5 , Corrado Aversa  6 , Maria Esposito  1 , Francesco Volzone  1 , Mariangela Saggese  1 , Gaetana Capobianco  1 , Sabrina Sarno  1 , Letizia Sirica  1 , Stefania Crisci  1 , Rosaria De Filippi  7 , Antonio Pinto  1
Affiliations
Clinical Trial

Long-term efficacy and safety of dose-dense and dose-intense ABVD without consolidation radiotherapy in patients with advanced Hodgkin lymphoma: A 15-year follow-up of the ABVDDD-DI phase II study

Gaetano Corazzelli et al. Br J Haematol. 2024 Oct.

Abstract

We demonstrated that dose-densified and dose-intensified ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine; ABVDDD-DI) was safe and effective. Here, we present a post hoc long-term analysis of the 82 patients enrolled in the original study. The median observation time was 175 months (IQR 159-197). At 15 years, progression-free and overall survival rates were 81.2% (95% CI, 69.9%-88.7%) and 92.7% (95% CI, 82.6%-97.0%), respectively. Four patients with multiple cardiovascular risk factors experienced delayed G3 cardiac events. The cumulative incidence of second malignancies at 20 years was 6.1%. Fertility and childbearing potential were unaffected. Data support an ongoing benefit for ABVDDD-DI without uneven late toxicities.

Keywords: ABVD; Hodgkin lymphoma; frontline intensification.

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