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Case Reports
. 2024 Jul 2;16(7):e63687.
doi: 10.7759/cureus.63687. eCollection 2024 Jul.

Immunotactoid Glomerulopathy Masquerading as Heart Failure

Kabeer Ali  1 , Avni Agrawal  1 , Abhinav Karan  1 , Christopher Marsalisi  1 , Melville C O'Brien  1 , Shiguang Liu  2 , Vishal Jaikaransingh  3
Affiliations
Case Reports

Immunotactoid Glomerulopathy Masquerading as Heart Failure

Kabeer Ali et al. Cureus. .

Abstract

Immunotactoid glomerulopathy (ITG) is a rare form of glomerular disease. It is characterized by organized, dense immunoglobulin deposits in the glomerulus, impairing glomerular function and filtration. The prognosis tends to be poor, and the majority of patients develop end-stage renal disease (ESRD). Here, we present a case of a young male with no prior medical history who presented with anasarca. His presentation was initially thought to be due to a new diagnosis of heart failure with a decreased ejection fraction. However, significant proteinuria led to a diagnosis of ITG.

Keywords: fibrillar glomerulopathy; immunotactoid; immunotactoid glomerulopathy; light chain deposition disease; tactoid body.

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Conflict of interest statement

Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. Chest radiograph showing bilateral pleural effusions, right greater than left (arrow)
Figure 2
Figure 2. Electron microscopy at 6000 times magnification showing immunotactoid deposition with a large diameter of microtubule deposits (average of 41 nm)
Figure 3
Figure 3. Electron microscopy image highlighting further immunotactoid deposits of smaller diameter
See this image and copyright information in PMC

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