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. 2024;11(5):1123-1130.
doi: 10.3233/JND-240081.

The Role of Cognition, Affective Symptoms, and Apathy in Treatment Adherence with Noninvasive Home Mechanical Ventilation in Myotonic Dystrophy

Bettine A H Vosse  1   2 , Jasmijn de Jong  1 , Leandre A la Fontaine  3   2 , Corinne G C Horlings  4 , Sander M J van Kuijk  5 , Nicolle A M Cobben  1 , Anne-Fleur Domensino  2   6 , Caroline van Heugten  2   6   7 , Catharina G Faber  3   2
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The Role of Cognition, Affective Symptoms, and Apathy in Treatment Adherence with Noninvasive Home Mechanical Ventilation in Myotonic Dystrophy

Bettine A H Vosse et al. J Neuromuscul Dis. 2024.

Abstract

Background: Chronic respiratory failure often occurs in myotonic dystrophy type 1 (DM1) and can be treated with noninvasive home mechanical ventilation (HMV). Treatment adherence with HMV is often suboptimal in patients with DM1, but the reasons for that are not well understood.

Objective: The aim of this exploratory study was to gain insight in the prevalence of mild cognitive impairment, affective symptoms, and apathy and to investigate their role in HMV treatment adherence in DM1.

Methods: The Montreal Cognitive Assessment (MoCA), the Hospital Anxiety and Depression Scale (HADS), and the Apathy Evaluation Scale (AES) were used to assess cognition, affective symptoms, and apathy in DM1 patients that use HMV. Patients with low treatment adherence (average daily use HMV <5 h or <80% of the days) were compared with patients with high treatment adherence (average daily use of HMV≥5 h and ≥80% of the days).

Results: Sixty patients were included. Abnormal scores were found in 40% of the total group for the MoCA, in 72-77% for the AES, and in 18% for HADS depression. There was no difference between the high treatment adherence group (n = 39) and the low treatment adherence group (n = 21) for the MoCA, AES, and HADS depression. The HADS anxiety was abnormal in 30% of the total group, and was significantly higher in the low treatment adherence group (p = 0.012). Logistic regression analysis revealed that a higher age and a higher BMI were associated with a greater chance of high treatment adherence.

Conclusions: This exploratory study showed that cognitive impairment and apathy are frequently present in DM1 patients that use HMV, but they are not associated with treatment adherence. Feelings of anxiety were associated with low treatment adherence. Higher age and higher BMI were associated with high treatment adherence with HMV.

Keywords: Treatment adherence; affective symptoms; apathy; artificial respiration; cognitive dysfunction; myotonic dystrophy; respiratory insufficiency.

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Conflict of interest statement

The authors have no conflict of interest to report.

Figures

Fig. 1
Fig. 1
Flow chart of the selection procedure.
Fig. 2
Fig. 2
Display of abnormal and normal scores of the main test results. MoCA = Montreal Cognitive Assessment, HADS = Hospital Anxiety and Depression Scale, AES-I = Apathy Evaluation Scale-Informant, AES-S = Apathy Evaluation Scale-Self.
See this image and copyright information in PMC

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