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. 2025 Jan 1;111(1):1517-1520.
doi: 10.1097/JS9.0000000000001984.

Transcutaneous auricular vagus nerve stimulation improves gastric motility and visceral hypersensitivity in rodents of functional dyspepsia by balancing duodenal immune response: an experimental study

Shaoyuan Li  1 , Ningyi Zou  1 , Bowen Feng  1 , Claire Marie Rangon  2   3 , Juan Han  1 , Lin Wang  4 , Yang Yang  4 , Wei Wei  4 , Peijing Rong  1   5
Affiliations

Transcutaneous auricular vagus nerve stimulation improves gastric motility and visceral hypersensitivity in rodents of functional dyspepsia by balancing duodenal immune response: an experimental study

Shaoyuan Li et al. Int J Surg. .
No abstract available

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Conflict of interest statement

The authors declare no conflicts of interest.

Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article.

Figures

Figure 1
Figure 1
Contents of motilin (MTL) in duodenum and changes of gastric emptying rates. (Control, n = 10 rats, IA, n=9 rats, taVNS, n=9 rats, SDVNS, n=8 rats, SDV+taVNS, n=8 rats, sham SDVNS, n=7 rats, SDV, n=8 rats); Data are presented as mean±SD. ns P>0.05; ***P<0.001 vs IA, respectively. IA, iodoacetamide; SDV, subdiaphragmatic vagotomy; SDVNS, subdiaphragmatic vagus nerve stimulation; taVNS, transcutaneous auricular vagus nerve stimulation.
Figure 2
Figure 2
Electromyography (EMG) waveforms changes response to gastric distension of 20, 40, 60 and 80 mmHg. (Control, n = 10 rats, IA, n=9 rats, taVNS, n=9 rats, SDVNS, n=8 rats, SDV+taVNS, n=8 rats, sham SDVNS, n=7 rats, SDV, n=8 rats); Data are presented as mean±SD. ns P>0.05; *P<0.05, **P<0.01, ***P<0.001 vs IA, respectively. IA, iodoacetamide; SDV, subdiaphragmatic vagotomy; SDVNS, subdiaphragmatic vagus nerve stimulation; taVNS, transcutaneous auricular vagus nerve stimulation.
Figure 3
Figure 3
Acetylcholine (Ach), nicotinic acetylcholine receptor α7 subunit (α7nAChR) and nuclear factor-kappa B (NF-кB) p65 levels in the duodenum. (Control, n = 10 rats, IA, n=9 rats, taVNS, n=9 rats, SDVNS, n=8 rats, SDV+taVNS, n=8 rats, sham SDVNS, n=7 rats, SDV, n=8 rats); Data are presented as mean±SD. ns P>0.05; **P<0.01, ***P<0.001 vs IA, respectively. IA, iodoacetamide; SDV, subdiaphragmatic vagotomy; SDVNS, subdiaphragmatic vagus nerve stimulation; taVNS, transcutaneous auricular vagus nerve stimulation.
See this image and copyright information in PMC

References

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