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Review
. 1985 Nov;5(4):309-17.
doi: 10.1055/s-2008-1040626.

Animal research in liver transplantation with special reference to the dog

S Todo, I Kam, S Lynch, T E Starzl
Review

Animal research in liver transplantation with special reference to the dog

S Todo et al. Semin Liver Dis. 1985 Nov.
No abstract available

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Figures

FIG. 1
FIG. 1. Auxiliary liver transplantation in dogs by a modification of Welch’s original technique
Note that the reconstituted portal blood supply is from the distal inferior vena cava. Cholecystoduodenostomy is performed. (Reproduced with permission from Starzl et al.8)
FIG. 2
FIG. 2. Orthotopic liver transplantation in dogs
(Reproduced with permission from Kam et al.19)
FIG. 3
FIG. 3. Method used in dogs for decompression of the inferior vena caval and splanchnic systems during removal of recipient liver and replacement with a homograft
Note that a preliminary portacaval shunt has been placed. By means of this temporary anastomosis, the two venous systems are connected, allowing their decompression with a single external bypass. (Reproduced with permission from Starzl et al.4)
FIG. 4
FIG. 4. Pump-driven veno-venous bypass used in dogs for decompression of inferior vena caval and splanchnic systems during anhepatic phase
(Reproduced with permission from Kam et al.19)
FIG. 5
FIG. 5. Preservation unit
The perfusion pumps are located outside the hyperbaric chamber; the organ receptacle, the oxygenator, and the venous reservoir are inside. The various chamber inlets permit sampling of the perfusate, gas sterilization, and oxygen delivery and removal. The temperature is electronically controlled. (Reproduced with permission from Brettschneider et al.27)
FIG. 6
FIG. 6. Changes in SGOT and total bilirubin of untreated dogs after orthotopic liver transplantation (OLTX)
(Reproduced with permission from Todo et al.32)
FIG. 7
FIG. 7. Changes in the survival rate of dogs among un-Nva2-Cs- and Cs-treated groups after orthotopic liver transplantation (OLTX)
(Reproduced with permission from Todo et al.32)
FIG. 8
FIG. 8. Changes in the blood level of Nva2-Cs and Cs in dogs after orthotopic liver transplantation (OLTX)
(Reproduced with permission from Todo et al.32)
See this image and copyright information in PMC

References

    1. Starzl TE, Marchioro TL, von Kaulla KN, et al. Homotransplantation of the liver in humans. Surg Gynecol Obstet. 1963;117:659–676. - PMC - PubMed
    1. Welch CW. A note on the transplantation of the whole liver in dogs. Transplant Bull. 1955;2:54–55.
    1. Moore FD, Wheeler HB, Demissianos HV, et al. Experimental whole-organ transplantation of the liver and of the spleen. ann Surg. 1960;152:374–387. - PMC - PubMed
    1. Starzl TE, Kaupp HA, Brock DR, et al. Reconstructive problems in canine liver homotransplantation with special reference to postoperative role of hepatic venous flow. Surg Gynecol Obstet. 1960;111:733–743. - PMC - PubMed
    1. Waddell WR. Starzl TE (Ed) with the assistance of Putnam CS: Experience in Hepatic Transplantation. Philadelphia: W.B. Saunders; 1969. Foreward; p. ix.

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