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. 1985 Aug 30;54(2):472-4.

The effects of nicotine on PGI2 production by rat aortic endothelium

H A Bull, R M Pittilo, D J Blow, C M Blow, P M Rowles, N Woolf, S J Machin
  • PMID: 3909501

The effects of nicotine on PGI2 production by rat aortic endothelium

H A Bull et al. Thromb Haemost. .

Abstract

The production of prostacyclin by rat aortic rings was measured following administration of nicotine by a single subcutaneous injection and after continuous subcutaneous infusion over 7 days. Single subcutaneous injections of nicotine at 1, 5, 10 or 20 mg/kg had no effect on prostacyclin production by rat aortic rings in comparison with controls. However, aortic rings obtained after 7 days continuous subcutaneous infusion of 0.54 g/ml of nicotine at the rate of 1 microliter per hour produced significantly less prostacyclin than control animals.

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