Long-Term Outcomes Following Hypoxic Ischemic Encephalopathy

Simone L Huntingford¹, Stephanie M Boyd², Sarah J McIntyre³, Shona C Goldsmith³, Rod W Hunt⁴, Nadia Badawi⁵

Affiliations

¹ Department of Paediatrics, Monash University, 246 Clayton Road, Clayton, Victoria 3168, Australia; Monash Newborn, Monash Health, 246 Clayton Road, Clayton, Victoria 3168, Australia; Paediatric Infant Perinatal Emergency Retrieval, Royal Children's Hospital, 50 Flemington Road, Parkville, Victoria 3052, Australia. Electronic address: Simone.huntingford@monashhealth.org.
² Grace Centre for Newborn Intensive Care, The Children's Hospital at Westmead, Hawkesbury Road, Westmead, New South Wales 2145, Australia; Faculty of Medicine and Health, University of Sydney, Campderdown, New South Wales 2006, Australia.
³ CP Alliance Research Institute, Specialty of Child and Adolescent Health, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
⁴ Department of Paediatrics, Monash University, 246 Clayton Road, Clayton, Victoria 3168, Australia; Monash Newborn, Monash Health, 246 Clayton Road, Clayton, Victoria 3168, Australia; CP Alliance Research Institute, Specialty of Child and Adolescent Health, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
⁵ Grace Centre for Newborn Intensive Care, The Children's Hospital at Westmead, Hawkesbury Road, Westmead, New South Wales 2145, Australia; CP Alliance Research Institute, Specialty of Child and Adolescent Health, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.

PMID: 39095104
DOI: 10.1016/j.clp.2024.04.008

Review

Long-Term Outcomes Following Hypoxic Ischemic Encephalopathy

Simone L Huntingford et al. Clin Perinatol. 2024 Sep.

. 2024 Sep;51(3):683-709.

doi: 10.1016/j.clp.2024.04.008. Epub 2024 May 28.

Authors

Simone L Huntingford¹, Stephanie M Boyd², Sarah J McIntyre³, Shona C Goldsmith³, Rod W Hunt⁴, Nadia Badawi⁵

Affiliations

¹ Department of Paediatrics, Monash University, 246 Clayton Road, Clayton, Victoria 3168, Australia; Monash Newborn, Monash Health, 246 Clayton Road, Clayton, Victoria 3168, Australia; Paediatric Infant Perinatal Emergency Retrieval, Royal Children's Hospital, 50 Flemington Road, Parkville, Victoria 3052, Australia. Electronic address: Simone.huntingford@monashhealth.org.
² Grace Centre for Newborn Intensive Care, The Children's Hospital at Westmead, Hawkesbury Road, Westmead, New South Wales 2145, Australia; Faculty of Medicine and Health, University of Sydney, Campderdown, New South Wales 2006, Australia.
³ CP Alliance Research Institute, Specialty of Child and Adolescent Health, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
⁴ Department of Paediatrics, Monash University, 246 Clayton Road, Clayton, Victoria 3168, Australia; Monash Newborn, Monash Health, 246 Clayton Road, Clayton, Victoria 3168, Australia; CP Alliance Research Institute, Specialty of Child and Adolescent Health, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
⁵ Grace Centre for Newborn Intensive Care, The Children's Hospital at Westmead, Hawkesbury Road, Westmead, New South Wales 2145, Australia; CP Alliance Research Institute, Specialty of Child and Adolescent Health, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.

PMID: 39095104
DOI: 10.1016/j.clp.2024.04.008

Abstract

Hypoxic ischemic encephalopathy (HIE) is the most common cause of neonatal encephalopathy and results in significant morbidity and mortality. Long-term outcomes of the condition encompass impairments across all developmental domains. While therapeutic hypothermia (TH) has improved outcomes for term and late preterm infants with moderate to severe HIE, trials are ongoing to investigate the use of TH for infants with mild or preterm HIE. There is no evidence that adjuvant therapies in combination with TH improve long-term outcomes. Numerous trials of various adjuvant therapies are underway in the quest to further improve outcomes for infants with HIE.

Keywords: Cerebral palsy (CP); Cognition; Hypoxic ischemic encephalopathy (HIE); Long-term; Neonatal; Neurodevelopmental (ND) outcome; Therapeutic hypothermia (TH).

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Conflict of interest statement

Disclosure The Neonatal Neurology Fellowship held by Dr S.L. Huntingford is funded by the Cerebral Palsy Alliance.

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Long-Term Outcomes Following Hypoxic Ischemic Encephalopathy

Affiliations

Long-Term Outcomes Following Hypoxic Ischemic Encephalopathy

Authors

Affiliations

Abstract

Conflict of interest statement

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous