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Review
. 2024 Sep;24(6):878-886.
doi: 10.1016/j.pan.2024.07.005. Epub 2024 Jul 15.

Epigenetic regulation of the tumor microenvironment: A leading force driving pancreatic cancer

Renzo Vera  1 , María Julia Lamberti  2 , Alina L Gonzalez  3 , Martín E Fernandez-Zapico  4
Affiliations
Review

Epigenetic regulation of the tumor microenvironment: A leading force driving pancreatic cancer

Renzo Vera et al. Pancreatology. 2024 Sep.

Abstract

Dysregulation of the epigenomic landscape of tumor cells has been implicated in the pathogenesis of pancreatic cancer. However, these alterations are not only restricted to neoplastic cells. The behavior of other cell populations in the tumor stroma such as cancer-associated fibroblasts, immune cells, and others are mostly regulated by epigenetic pathways. Here, we present an overview of the main cellular and acellular components of the pancreatic cancer tumor microenvironment and discuss how the epigenetic mechanisms operate at different levels in the stroma to establish a differential gene expression to regulate distinct cellular phenotypes contributing to pancreatic tumorigenesis.

Keywords: Epigenetics; Gene expression; Pancreatic cancer; Stroma; Tumor microenvironment.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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