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. 2024 Aug 2;22(1):93.
doi: 10.1186/s12958-024-01259-x.

Oxidative stress biomarkers in pregnancy: a systematic review

Abubakar Ibrahim  1 , Martina Irwan Khoo  2 , Engku Husna Engku Ismail  1 , Nik Hazlina Nik Hussain  3 , Anani Aila Mat Zin  4 , Liza Noordin  5 , Sarimah Abdullah  6 , Zaleha Abdullah Mahdy  7 , Nik Ahmad Zuky Nik Lah  8
Affiliations

Oxidative stress biomarkers in pregnancy: a systematic review

Abubakar Ibrahim et al. Reprod Biol Endocrinol. .

Abstract

Background: This systematic review explores the level of oxidative stress (OS) markers during pregnancy and their correlation with complications. Unlike previous studies, it refrains from directly investigating the role of OS but instead synthesises data on the levels of these markers and their implications for various pregnancy-related complications such as preeclampsia, intrauterine growth restrictions, preterm premature rupture of membranes, preterm labour, gestational diabetes mellitus and miscarriages.

Method: STUDY DESIGN: Utilizing a systematic review approach, we conducted a comprehensive search across databases, including MEDLINE, CINAHL (EBSCOhost), ScienceDirect, Web of Science, and SCOPUS. Our search encompassed all publication years in English.

Results: After evaluating 54,173 records, 45 studies with a low risk of bias were selected for inclusion. This systematic review has underscored the importance of these markers in both physiological and pathological pregnancy states such as preeclampsia, intrauterine growth restrictions, preterm premature rupture of membranes, preterm labour, gestational diabetes mellitus and miscarriages.

Conclusion: This systematic review provides valuable insights into the role of OS in pregnancy and their connection to complications. These selected studies delved deeply into OS markers during pregnancy and their implications for associated complications. The comprehensive findings highlighted the significance of OS markers in both normal and pathological pregnancy conditions, paving the way for further research in this field.

Keywords: Antioxidants; Biomarkers; Fetal growth restriction; Oxidative stress; Pre-eclampsia; Pregnancy.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Prepared reporting item for systematic review and meta-analysis. (n = number of records)
See this image and copyright information in PMC

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