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. 1985;49(5):331-5.
doi: 10.1111/j.1423-0410.1985.tb00807.x.

Alloimmunisation to HLA antigens following transfusion with leucocyte-poor and purified platelet suspensions

M Fisher, J R Chapman, A Ting, P J Morris

Alloimmunisation to HLA antigens following transfusion with leucocyte-poor and purified platelet suspensions

M Fisher et al. Vox Sang. 1985.

Abstract

24 previously non-transfused patients were given three transfusions of 200 X 10(8) platelets at 14-day intervals. Group I (12 patients) received leucocyte-poor platelet suspensions with a mean contamination of 15 X 10(6) leucocytes per transfusion. Group II (12 patients) received platelets with less than 5 X 10(6) leucocytes per transfusion. 5 patients in group I and no patients in group II developed lymphocytotoxic antibodies (p = 0.037). Platelets with fewer than 5 X 10(6) leucocytes did not seem to stimulate a response to major histocompatibility antigens, but with a small contaminating dose of leucocytes appeared to be highly immunogenic.

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