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. 2024 Aug 3;14(8):e083444.
doi: 10.1136/bmjopen-2023-083444.

Surveillance of antibiotics use in inpatients at Benjamin Mkapa Zonal Referral Hospital in Dodoma, Tanzania: a point prevalence survey

Kauke Bakari Zimbwe  1 , Yusto Julius Yona  2 , Charity Alphonce Chiwambo  3 , Alphonce Bilola Chandika  4 , Humphrey Sawira Kiwelu  5 , Omary Salim Kizenga  6 , Mfaume Michael Mleke  2 , Moshi Moshi Shabani  7
Affiliations

Surveillance of antibiotics use in inpatients at Benjamin Mkapa Zonal Referral Hospital in Dodoma, Tanzania: a point prevalence survey

Kauke Bakari Zimbwe et al. BMJ Open. .

Abstract

Objective: To assess antibiotics prescribing and use patterns for inpatients at Benjamin Mkapa Zonal Referral Hospital (BMH) using the WHO-Point Prevalence Survey (WHO-PPS).

Design: A cross-sectional survey.

Setting: The Benjamin Mkapa Zonal Referral Hospital, Dodoma, Tanzania.

Participants: Inpatient prescriptions, regardless of whether antibiotics were prescribed (n=286) on the day of PPS.

Outcome measures: Our study analysed the prevalence of antibiotic use at BMH for inpatients, the type of antibiotics used, the indications for use and the proportion of oral and parenteral antibiotics. We also assessed prescription-prescribed antibiotics after a positive antimicrobial susceptibility testing (AST) result.

Results: A survey was conducted on 286 prescriptions, which revealed that 30.07% of them included antibiotics. On average, each prescription contained at least 1.6 antibiotics. All prescriptions that included antibiotics were written in generic names, and 77.91% (67/86) of them followed the Standard Treatment Guidelines. Of the prescriptions that included antibiotics, 58.14% (50/86) had a single antibiotic, 20.93% (18/86) had parenteral antibiotics and 79.07% (68/86) had oral antibiotics. Based on AWaRe's (Access, Watch and Reserve) categorisation of antibiotics, 50% (8/16) were in the Access group, 31.25% (5/16) were in the Watch group, 12.50% (2/16) were in the Reserve group and 6.25% (1/16) were not recommended antimicrobial combinations. Out of 86 prescriptions included antibiotics, only 4.65% showed positive culture growth. However, antibiotics were still prescribed in 29.07% of prescriptions where there was no growth of bacteria, and in 66.28% of prescriptions, antibiotics were prescribed empirically without any requesting of bacteria culture and AST.

Conclusion: BMH has reduced inpatient Antibiotic Use by half compared with the 2019 WHO-PPS. Adherence to National Treatment Guidelines is suboptimal. Clinicians should use AST results to guide antibiotic prescribing.

Keywords: bacteriology; clinical pharmacology; infectious diseases; inpatients; medication reconciliation; patients.

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Conflict of interest statement

Competing interests: None declared.

References

    1. World Health Organization WHO methodology for point prevalence survey on antibiotic use in hospitals. 2018. pp. 1–102.https://www.who.int/publications/i/item/WHO-EMP-IAU-2018.01 Available.
    1. Kiggundu R, Lusaya E, Seni J, et al. Identifying and addressing challenges to antimicrobial use surveillance in the human health sector in low- and middle-income countries: experiences and lessons learned from Tanzania and Uganda. Antimicrob Resist Infect Control. 2023;12:9. doi: 10.1186/s13756-023-01213-3. - DOI - PMC - PubMed
    1. Jamaluddin NAH, Periyasamy P, Lau CL, et al. Point Prevalence Survey of Antimicrobial Use in a Malaysian Tertiary Care University Hospital. Antibiotics (Basel) -> Antibiotics (Basel) 2021;10:1–13. doi: 10.3390/antibiotics10050531. - DOI - PMC - PubMed
    1. Gandra S, Alvarez-Uria G, Murki S, et al. Point prevalence surveys of antimicrobial use among eight neonatal intensive care units in India: 2016. Int J Infect Dis. 2018;71:20–4. doi: 10.1016/j.ijid.2018.03.017. - DOI - PMC - PubMed
    1. Abubakar U. Antibiotic use among hospitalized patients in northern nigeria: A multicenter point-prevalence survey. BMC Infect Dis. 2020;20:86. doi: 10.1186/s12879-020-4815-4. - DOI - PMC - PubMed

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