Is bivalirudin ready for a comeback? Pros and cons
- PMID: 39099374
- PMCID: PMC11287373
- DOI: 10.4244/EIJ-E-24-00013
Is bivalirudin ready for a comeback? Pros and cons
Conflict of interest statement
R.H. Stables has no conflicts of interest to declare.
Figures

References
-
- Stone GW, Witzenbichler B, Guagliumi G, Peruga JZ, Brodie BR, Dudek D, Kornowski R, Hartmann F, Gersh BJ, Pocock SJ, Dangas G, Wong SC, Kirtane AJ, Parise H, Mehran R HORIZONS-AMI Trial Investigators. Bivalirudin during primary PCI in acute myocardial infarction. N Engl J Med. 2008;358:2218–30. - PubMed
-
- Li Y, Liang Z, Qin L, Wang M, Wang X, Zhang H, Liu Y, Li Y, Jia Z, Liu L, Zhang H, Luo J, Dong S, Guo J, Zhu H, Li S, Zheng H, Liu L, Wu Y, Zhong Y, Qiu M, Han Y, Stone GW. Bivalirudin plus a high-dose infusion versus heparin monotherapy in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: a randomised trial. Lancet. 2022;400:1847–57. - PubMed
-
- Byrne RA, Rossello X, Coughlan JJ, Barbato E, Berry C, Chieffo A, Claeys MJ, Dan GA, Dweck MR, Galbraith M, Gilard M, Hinterbuchner L, Jankowska EA, Jüni P, Kimura T, Kunadian V, Leosdottir M, Lorusso R, Pedretti RFE, Rigopoulos AG, Rubini Gimenez M, Thiele H, Vranckx P, Wassmann S, Wenger NK, Ibanez B. 2023 ESC Guidelines for the management of acute coronary syndromes. Eur Heart J. 2023;44:3720–826. - PubMed
-
- Bikdeli B, Erlinge D, Valgimigli M, Kastrati A, Han Y, Steg PG, Stables RH, Mehran R, James SK, Frigoli E, Goldstein P, Li Y, Shahzad A, Schüpke S, Mehdipoor G, Chen S, Redfors B, Crowley A, Zhou Z, Stone GW. Bivalirudin Versus Heparin During PCI in NSTEMI: Individual Patient Data Meta-Analysis of Large Randomized Trials. Circulation. 2023;148:1207–19. - PubMed
-
- Stone GW. . Bivalirudin Is the Most Evidence Based Antithrombin Agent for Primary PCI. Presented at TCT 2023: 23-26 October 2023, San Francisco, CA, USA; TCT 2023; 23-26 October 2023; San Francisco, CA, USA. Presented at TCT 2023: 23-26 October 2023, San Francisco, CA, USA.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources