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. 2024 Jul 18;11(8):ofae400.
doi: 10.1093/ofid/ofae400. eCollection 2024 Aug.

Prevalence and Risk Factors of Cytomegalovirus Among Men Having Sex With Men Enrolled in a Pre-Exposure Prophylaxis Study

Sylvain Chawki  1   2 , Nicolas Leturque  3 , Marine Minier  4 , Audrey Gabassi  4 , Valérie Foubert  3 , Isabelle Charreau  3 , Eric Cua  5 , Gilles Pialoux  6 , Laurence Meyer  3 , Jean-Michel Molina  1   2 , Constance Delaugerre  2   4
Affiliations

Prevalence and Risk Factors of Cytomegalovirus Among Men Having Sex With Men Enrolled in a Pre-Exposure Prophylaxis Study

Sylvain Chawki et al. Open Forum Infect Dis. .

Abstract

Risk factors for cytomegalovirus (CMV) acquisition in men having sex with men remain unclear. Seroprevalence, incidence, risk factors and shedding of CMV were analyzed among participants enrolled in the HIV pre-exposure prophylaxis IPERGAY-ANRS trial. Among the 417 participants tested, 382 were seropositive at baseline (prevalence of 91.6%; 95%CI[88.5-94.1]) and 10/35 seroconverted during the study (incidence of 17.1 per 100 person-years; 95%CI[8.2-31.3]). A high number of sexual partners was independently associated with CMV seroprevalence. Shedding among CMV-seroconverters was reported for 6/9 and 2/9 at the oral and anal levels, respectively. Our data supports transmission of CMV during sexual contacts.

Study part of the anrs-ipergay clinical trial: ClinicalTrials.gov number, NCT01473472.

Keywords: CMV; MSM; behavior; risk-factors; seroconversion.

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Conflict of interest statement

Potential conflicts of interest. All authors: No reported conflicts.

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