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Review
. 2024 Jul 19:15:1421854.
doi: 10.3389/fimmu.2024.1421854. eCollection 2024.

Advances and clinical challenges of mesenchymal stem cell therapy

Ruiyan Mei #  1 , Zhuo Wan #  2 , Cheng Yang #  1 , Xiangjing Shen  1 , Ronglin Wang  1 , Haihua Zhang  1 , Rui Yang  1 , Junqiang Li  1 , Yang Song  1 , Haichuan Su  1
Affiliations
Review

Advances and clinical challenges of mesenchymal stem cell therapy

Ruiyan Mei et al. Front Immunol. .

Abstract

In recent years, cell therapy has provided desirable properties for promising new drugs. Mesenchymal stem cells are promising candidates for developing genetic engineering and drug delivery strategies due to their inherent properties, including immune regulation, homing ability and tumor tropism. The therapeutic potential of mesenchymal stem cells is being investigated for cancer therapy, inflammatory and fibrotic diseases, among others. Mesenchymal stem cells are attractive cellular carriers for synthetic nanoparticles for drug delivery due to their inherent homing ability. In this review, we comprehensively discuss the various genetic and non-genetic strategies of mesenchymal stem cells and their derivatives in drug delivery, tumor therapy, immune regulation, tissue regeneration and other fields. In addition, we discuss the current limitations of stem cell therapy and the challenges in clinical translation, aiming to identify important development areas and potential future directions.

Keywords: cell homing; clinical use; drug delivery; mesenchymal stem cell; nanoparticles.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Origin and mechanism of mesenchymal stem cells. (A) Mesenchymal stem cells come from bone marrow, adipose tissue, umbilical cord, muscle and other tissues, and can differentiate into different cell types. (B) Schematic diagram of homing mechanism of mesenchymal stem cells.
Figure 2
Figure 2
Mesenchymal stem cells and their derivatives are used for drug delivery. Mesenchymal stem cells and their derivatives can deliver a variety of drugs to different tissues throughout the body, such as the heart, liver, and lung.
See this image and copyright information in PMC

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