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Editorial
. 2024 Jul 31;13(7):1319-1323.
doi: 10.21037/tau-24-8. Epub 2024 Jul 4.

Imposter among us: field cancerization in the bladder

Daniel J Rodden  1   2 , Ella H Chung  1   2 , Rea Pittie  1   2 , David T Miyamoto  1   2   3
Affiliations
Editorial

Imposter among us: field cancerization in the bladder

Daniel J Rodden et al. Transl Androl Urol. .
No abstract available

Keywords: Field cancerization; T-cell exhaustion; bladder cancer; programmed cell death protein 1 (PD-1); urinary tumor DNA.

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tau.amegroups.com/article/view/10.21037/tau-24-8/coif). D.T.M. reports funding from the NIH providing support for the present manuscript, and funding from the Radiation Oncology Institute unrelated to the present manuscript. The other authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
High field cancerization in bladder cancer leads to lower short-term HG-RFS after bacillus Calmette-Guérin therapy in part due to elevated TMB and neoantigen load and exhausted T-cells. Total mutational burden from both the tumor and the field cancerization is reflected in higher levels of utDNA. Created with BioRender.com. HG-RFS, high-grade recurrence-free survival; TMB, tumor mutational burden; utDNA, urine tumor DNA.
See this image and copyright information in PMC

Comment on

References

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