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. 2024 Aug 6;40(1):197-203.
doi: 10.1515/reveh-2023-0152. Print 2025 Mar 26.

Tributyltin induces apoptosis in mammalian cells in vivo: a scoping review

Lucas Vilas Bôas Correia  1 , Talita Trindade de Moraes  1 , Aparecida Marta Regina Dos Santos Pereira  1 , Gabriel Carvalhal de Aguiar  1 , Milena de Barros Viana  1 , Daniel Araki Ribeiro  1 , Regina Cláudia Barbosa da Silva  1
Affiliations
Free article

Tributyltin induces apoptosis in mammalian cells in vivo: a scoping review

Lucas Vilas Bôas Correia et al. Rev Environ Health. .
Free article

Abstract

The present review aimed to evaluate the apoptotic effect of tributyltin (TBT) exposure on mammalian tissues and cells in vivo. A search was conducted in specialized literature databases including Embase, Medline, Pubmed, Scholar Google, and Scopus for all manuscripts using the following keywords: "tributyltin", "apoptosis", "mammals", "mammalian cells', "eukaryotic cells", 'rodents', "rats", "mice" and "in vivo" for all data published until September 2023. A total of 16 studies were included. The studies have demonstrated that TBT exposure induces apoptosis in cells from various mammalian organs or tissues in vivo. TBT is capable to increase apoptotic cells, to activate proapoptotic proteins such as calpain, caspases, bax and beclin-1 and to inhibit antiapoptotic protein bcl-2. Additionally, TBT alters the ratio of bcl-2/bax which favor apoptosis. Therefore, the activation of enzymes such as calpain induces apoptosis mediated by ERS and caspases through the intrinsic apoptosis pathway. This review has demonstrated that TBT exposure induces apoptosis in mammalian tissues and cells in vivo.

Keywords: in vivo; ERS; TBT; apoptosis; intrinsic pathway; mammalian cells.

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