Unveiling the Causal Relationship of Cardiovascular Burden in Primary Aldosteronism by Genome-Wide Association and Mendelian Randomization: A Possible Solution?

doi:10.1161/JAHA.124.036496

Editorial

. 2024 Aug 6;13(15):e036496.

doi: 10.1161/JAHA.124.036496. Epub 2024 Aug 5.

Unveiling the Causal Relationship of Cardiovascular Burden in Primary Aldosteronism by Genome-Wide Association and Mendelian Randomization: A Possible Solution?

Cheng-Hsuan Tsai^{1

2}, Tai-Shuan Lai^{2

3}, Yen-Hung Lin^{1

2}

Affiliations

¹ Division of Cardiology, Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan.
² National Taiwan University Hospital Primary Aldosteronism Center Taipei Taiwan.
³ Division of Nephrology, Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan.

PMID: 39101512
PMCID: PMC11964005
DOI: 10.1161/JAHA.124.036496

Editorial

Unveiling the Causal Relationship of Cardiovascular Burden in Primary Aldosteronism by Genome-Wide Association and Mendelian Randomization: A Possible Solution?

Cheng-Hsuan Tsai et al. J Am Heart Assoc. 2024.

. 2024 Aug 6;13(15):e036496.

doi: 10.1161/JAHA.124.036496. Epub 2024 Aug 5.

Authors

Cheng-Hsuan Tsai^{1

2}, Tai-Shuan Lai^{2

3}, Yen-Hung Lin^{1

2}

Affiliations

¹ Division of Cardiology, Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan.
² National Taiwan University Hospital Primary Aldosteronism Center Taipei Taiwan.
³ Division of Nephrology, Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan.

PMID: 39101512
PMCID: PMC11964005
DOI: 10.1161/JAHA.124.036496

No abstract available

Keywords: Editorials; cardiovascular disease; genome‐wide association study; primary aldosteronism.

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Figures

**Figure 1. Causal relationship of cardiovascular disease in primary aldosteronism.**
Illustration of potential genetic risks associated with cardiovascular diseases in patients with primary aldosteronism, as identified through genome‐wide association and Mendelian randomization studies. CAD indicates coronary artery disease; and CHF, congestive heart failure.

See this image and copyright information in PMC

Comment on

Primary Aldosteronism and Risk of Cardiovascular Outcomes: Genome-Wide Association and Mendelian Randomization Study.
Inoue K, Naito T, Fuji R, Sonehara K, Yamamoto K, Baba R, Kodama T, Otagaki Y, Okada A, Itcho K, Kobuke K, Ohno H; BioBank Japan; Morisaki T, Hattori N, Goto A, Nishikawa T, Oki K, Okada Y. Inoue K, et al. J Am Heart Assoc. 2024 Aug 6;13(15):e034180. doi: 10.1161/JAHA.123.034180. Epub 2024 Aug 5. J Am Heart Assoc. 2024. PMID: 39101507 Free PMC article.

References

1. Monticone S, D'Ascenzo F, Moretti C, Williams TA, Veglio F, Gaita F, Mulatero P. Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta‐analysis. Lancet Diabetes Endocrinol. 2018;6:41–50. doi: 10.1016/S2213-8587(17)30319-4 - DOI - PubMed
1. Tsai CH, Pan CT, Chang YY, Chen ZW, Wu VC, Hung CS, Lin YH. Left ventricular remodeling and dysfunction in primary aldosteronism. J Hum Hypertens. 2021;35:131–147. doi: 10.1038/s41371-020-00426-y - DOI - PMC - PubMed
1. Inoue K, Naito T, Fuji R, Sonehara K, Yamamoto K, Baba R, Kodama T, Otagaki Y, Okada A, Itcho K. Primary aldosteronism and risk of cardiovascular outcomes: genome‐wide association and Mendelian randomization study. J Am Heart Assoc. 2024. doi: 10.1161/JAHA.123.034180 - DOI - PMC - PubMed
1. Naito T, Inoue K, Sonehara K, Baba R, Kodama T, Otagaki Y, Okada A, Itcho K, Kobuke K, Kishimoto S, et al. Genetic risk of primary aldosteronism and its contribution to hypertension: a cross‐ancestry meta‐analysis of genome‐wide association studies. Circulation. 2023;147:1097–1109. doi: 10.1161/CIRCULATIONAHA.122.062349 - DOI - PMC - PubMed
1. Le Floch E, Cosentino T, Larsen CK, Beuschlein F, Reincke M, Amar L, Rossi GP, de Sousa K, Baron S, Chantalat S, et al. Identification of risk loci for primary aldosteronism in genome‐wide association studies. Nat Commun. 2022;13:5198. doi: 10.1038/s41467-022-32896-8 - DOI - PMC - PubMed

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[1] Monticone S, D'Ascenzo F, Moretti C, Williams TA, Veglio F, Gaita F, Mulatero P. Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta‐analysis. Lancet Diabetes Endocrinol. 2018;6:41–50. doi: 10.1016/S2213-8587(17)30319-4 - DOI - PubMed

[2] Monticone S, D'Ascenzo F, Moretti C, Williams TA, Veglio F, Gaita F, Mulatero P. Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta‐analysis. Lancet Diabetes Endocrinol. 2018;6:41–50. doi: 10.1016/S2213-8587(17)30319-4 - DOI - PubMed

[3] Tsai CH, Pan CT, Chang YY, Chen ZW, Wu VC, Hung CS, Lin YH. Left ventricular remodeling and dysfunction in primary aldosteronism. J Hum Hypertens. 2021;35:131–147. doi: 10.1038/s41371-020-00426-y - DOI - PMC - PubMed

[4] Tsai CH, Pan CT, Chang YY, Chen ZW, Wu VC, Hung CS, Lin YH. Left ventricular remodeling and dysfunction in primary aldosteronism. J Hum Hypertens. 2021;35:131–147. doi: 10.1038/s41371-020-00426-y - DOI - PMC - PubMed

[5] Inoue K, Naito T, Fuji R, Sonehara K, Yamamoto K, Baba R, Kodama T, Otagaki Y, Okada A, Itcho K. Primary aldosteronism and risk of cardiovascular outcomes: genome‐wide association and Mendelian randomization study. J Am Heart Assoc. 2024. doi: 10.1161/JAHA.123.034180 - DOI - PMC - PubMed

[6] Inoue K, Naito T, Fuji R, Sonehara K, Yamamoto K, Baba R, Kodama T, Otagaki Y, Okada A, Itcho K. Primary aldosteronism and risk of cardiovascular outcomes: genome‐wide association and Mendelian randomization study. J Am Heart Assoc. 2024. doi: 10.1161/JAHA.123.034180 - DOI - PMC - PubMed

[7] Naito T, Inoue K, Sonehara K, Baba R, Kodama T, Otagaki Y, Okada A, Itcho K, Kobuke K, Kishimoto S, et al. Genetic risk of primary aldosteronism and its contribution to hypertension: a cross‐ancestry meta‐analysis of genome‐wide association studies. Circulation. 2023;147:1097–1109. doi: 10.1161/CIRCULATIONAHA.122.062349 - DOI - PMC - PubMed

[8] Naito T, Inoue K, Sonehara K, Baba R, Kodama T, Otagaki Y, Okada A, Itcho K, Kobuke K, Kishimoto S, et al. Genetic risk of primary aldosteronism and its contribution to hypertension: a cross‐ancestry meta‐analysis of genome‐wide association studies. Circulation. 2023;147:1097–1109. doi: 10.1161/CIRCULATIONAHA.122.062349 - DOI - PMC - PubMed

[9] Le Floch E, Cosentino T, Larsen CK, Beuschlein F, Reincke M, Amar L, Rossi GP, de Sousa K, Baron S, Chantalat S, et al. Identification of risk loci for primary aldosteronism in genome‐wide association studies. Nat Commun. 2022;13:5198. doi: 10.1038/s41467-022-32896-8 - DOI - PMC - PubMed

[10] Le Floch E, Cosentino T, Larsen CK, Beuschlein F, Reincke M, Amar L, Rossi GP, de Sousa K, Baron S, Chantalat S, et al. Identification of risk loci for primary aldosteronism in genome‐wide association studies. Nat Commun. 2022;13:5198. doi: 10.1038/s41467-022-32896-8 - DOI - PMC - PubMed

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Unveiling the Causal Relationship of Cardiovascular Burden in Primary Aldosteronism by Genome-Wide Association and Mendelian Randomization: A Possible Solution?

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Unveiling the Causal Relationship of Cardiovascular Burden in Primary Aldosteronism by Genome-Wide Association and Mendelian Randomization: A Possible Solution?

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