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Editorial
. 2024 Aug 1;25(8):775-777.
doi: 10.1097/PCC.0000000000003533. Epub 2024 Aug 5.

Randomized Trials to Reduce Clinical Uncertainty: Gold Standard or Fool's Gold?

Mark J Peters  1   2   3 , Padmanabhan Ramnarayan  3   4
Affiliations
Editorial

Randomized Trials to Reduce Clinical Uncertainty: Gold Standard or Fool's Gold?

Mark J Peters et al. Pediatr Crit Care Med. .
No abstract available

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Conflict of interest statement

Prof. Peters’ institution received funding from the U.K. National Institute of Health and Care Research Health Technology Assessment program. Dr. Ramnarayan has disclosed that he does not have any potential conflicts of interest.

References

    1. Goligher EC, Kavanagh BP, Rubenfeld GD, et al.: Oxygenation response to positive end-expiratory pressure predicts mortality in acute respiratory distress syndrome. A secondary analysis of the LOVS and ExPress trials. Am J Respir Crit Care Med. 2014; 190:70–76
    1. Peters MJ, Ramnarayan P, Scholefield BR, et al.; United Kingdom Paediatric Critical Care Society Study Group (PCCS-SG): The United Kingdom Paediatric Critical Care Society Study Group: The 20-year journey toward pragmatic, randomized clinical trials. Pediatr Crit Care Med. 2022; 23:1067–1075
    1. González-Dambrauskas S, Jaramillo-Bustamante JC, Díaz F: No one is better than all together: The role of networks in pediatric intensive care. Rev Bras Ter Intensiva. 2019; 31:277–281
    1. Randolph AG, Bembea MM, Cheifetz IM, et al.; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network: Pediatric Acute Lung Injury and Sepsis Investigators (PALISI): Evolution of an investigator-initiated research network. Pediatr Crit Care Med. 2022; 23:1056–1066
    1. Peters MJ, Gould DW, Ray S, et al.; Oxy-PICU Investigators of the Paediatric Critical Care Society Study Group (PCCS-SG): Conservative versus liberal oxygenation targets in critically ill children (Oxy-PICU): A UK multicentre, open, parallel-group, randomised clinical trial. Lancet. 2023; 403:355–364

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